Menopausal hormone therapy (MHT) is the most effective method of treating vasomotor symptoms and other climacteric symptoms related to estrogen deficiency in peri- and postmenopausal period. In addition to estrogen replacement, women with preserved uterus require the addition of progestagen in order to ensure endometrial safety. One of rare but severe complications of MHT is venous thromboembol...

Endometrial stromal sarcoma is known to be a hormone-dependent tumor. Efficacy of hormonal therapy including high-dose progestins, aromatase inhibitors or gonadotropin-releasing hormone analogs has been reported. We report a case of recurrent endometrial stromal sarcoma, the tumor cells of which were strongly positive for CD10, estrogen and progesterone receptors. Although almost all of the pel...

background: luteal phase support is mandatory in art (assisted reproductive technologies) for optimizing outcome, so the luteal phase is supported with either progesterone, addition of estradiol to progesterone, hcg or gonadotropin releasing hormone (gnrh) agonists. supplementation of luteal phase with progesterone is prescribed for women undergoing routine ivf treatment. objective: to compare ...

AIM To evaluate differences in uteroplacental blood flow and pregnancy outcome in women with idiopathic recurrent spontaneous miscarriage (IRSM) following administration of micronized vaginal progesterone and oral dydrogesterone. METHODS One hundred and thirty-three women (aged 23-40 years) who had had early miscarriages and spontaneous conception participated. Oral dydrogesterone (group A, n...

Background: Abnormal uterine bleeding is defined as irregularities in the menstrual cycle involving frequency, regularity, duration, and volume of flow outside pregnancy. Up to 1/3rd women experience abnormal their life, with most commonly occurs at menarche perimenopause due disruption hypothalamic-pituitary-ovarian axis. Aim: To compare effectiveness Norethisterone Dydrogesterone for treatmen...

The aim of this study was to compare the effects of oral and suppository of Progesterone in pregnant women lower than 12th weeks of gestation with threatened abortion to prevent miscarriage. This random clinical trial study was conducted on 200 pregnant women with threatened abortion and gestational age ≤ 12 weeks who were referred to Kosar obstetrics and gynecology clinic in Shahid Motahari ho...

BACKGROUND Miscarriage is a common complication of pregnancy occurring in 15-20 % of all clinically recognized pregnancies. Currently, there is still no good scientific evidence to support the routine use of progestogens for the treatment of threatened miscarriage because the existing studies were not large enough to show a significant difference and some of them were not randomized or double-b...

Clinical observations and basic studies show that progesterone and progestins have a variable influence on endothelial function. Dydrogesterone (DG) is a widely used progestin, but its endothelial actions have not been thoroughly assessed. In this study, we investigated the effects of DG and its metabolite 20-α-dihydro-dydrogesterone (DHD), natural progesterone as well as medroxyprogesterone ac...

Main results 10 studies (531 women) of 14 published trials testing the efficacy of progesterone met the selection criteria. 1 study used both suppositories and oral preparations and was treated as 2 studies in the meta-analysis. The pooled results for 8 studies on suppositories and 3 studies on oral drugs showed a small benefit for progesterone in the reduction of symptoms (table). When results...

OBJECTIVE To evaluate the lowest effective dose of combined estrogen and progestogen (E(2)+P) add-back therapy during post-operative gonadotropin-releasing hormone agonist (GnRHa) treatment for endometriosis in Chinese women. STUDY DESIGN The study enrolled 81 patients aged 18 to 50 years with stage III or IV endometriosis, as diagnosed by surgery. All patients were given GnRHa 3.6 mg by subc...