Epidermal growth factor receptor (EGFR) and receptor tyrosine-protein kinase 3 (ErbB3) are two well-established targets in cancer therapy. There is significant crosstalk among these two receptors and others. To block signaling from both EGFR and ErbB3, we generated anti-EGFR and anti-ErbB3 DVD-Ig proteins. Two DVD-Ig proteins maintained the functions of the combination of the two parental antib...

Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) or Smad5(DVD), even though all three Smad(DVD)s associated with Smad4 and boun...

Dissociated strabismus complex (DSC), comprising dissociated vertical deviation (DVD), dissociated horizontal deviation (DHD), and dissociated torsional deviation (DTD), is an enigmatic ocular misalignment disorder, for which multiple causes have been hypothesized. Evidence-based studies evaluating the pathophysiology of this unusual ocular motility disorder is of value to existing knowledge. L...

This paper analyzes a model of consumer adoption of DVD players (the hardware-side) and movie studios’ supply of movies on DVD discs (the softwareside). My primary focus is the estimation of complementarities between DVD player adoption and availability of content on DVD discs. The size of the complementarities determine the level of strategic inter-dependence between hardware and software firm...

Diaveridine (DVD) is used in combination with sulphachloropyrazine (SPZ) as an effective antibacterial agent and antiprotozoal agent, respectively, in humans and animals. To gain a better understanding of the metabolism of SPZ and DVD in the food-producing animals, a high performance liquid chromatography (HPLC) method to determine and quantify sulphachloropyrazine (SPZ) and diaveridine (DVD) s...

BACKGROUND In Solomon Islands many people with Tuberculosis (TB) have challenges in accessing services because of socio-cultural, geographic and health service reasons, resulting in delays in TB treatment and low detection rates. The purpose of this project was to (i) develop a local language audio-visual resource (DVD) about TB (ii) share this resource with people in remote villages and (iii) ...

OBJECTIVE We evaluated the impact of an automated decision support tool (DST) on clinicians' ability to identify glycemic abnormalities in structured self-monitoring of blood glucose (SMBG) data and then make appropriate therapeutic changes based on the glycemic patterns observed. RESEARCH DESIGN AND METHODS In this prospective, randomized, controlled, multicenter study, 288 clinicians (39.6%...

dvdauthor is an excellent low-level free tool for video DVD authoring on Unix systems. However, it doesn’t provide a convenient way for drawing the menu background and buttons. We present dvdmenuauthor, a collection of scripts for automated DVD authoring with menus. dvdmenuauthor uses pdfLATEX macros for menu composition, Xpdf for menu rendering, and dvdauthor for DVD filesystem authoring.

BACKGROUND Self-directed BLS-training, using a personal training manikin with video has been shown to be as effective as instructor-led training. This has not previously been investigated for AED-training. MATERIALS AND METHODS This prospective, randomized study with a non-inferiority design compared traditional instructor-led training with three DVD-based AED-training methods (2.5min DVD wit...