s | 49 Aims: This project aims to assess whether systemic treatment with ketamine may improve the behavioural response in an animal model of a treatment resistant condition. Methods: Male Sprague-Dawley rats received subcutaneous injections of ACTH (100ug/rat/day) or vehicle during 14 days. On the 14th day the animals were exposed to the pre-test session of forced swim (FST) and after 24h they ...

In the present study, an attempt was made to compare the statistical tools used for analysing the data of repeated dose toxicity studies with rodents conducted in 45 countries, with that of Japan. The study revealed that there was no congruence among the countries in the use of statistical tools for analysing the data obtained from the above studies. For example, to analyse the data obtained fr...

Introduction: Owing to the variety of materials and methods employed, comparison of the results and findings from bonding studies is difficult. Until recently, several types of teeth have been used in published research papers as a substrate in orthodontic bonding research including bovine incisors, fresh and rebonded human premolars. Objectives: The purpose of this study was to compare the she...

This experiment was designed to study the effects of caffeine on histomorphology testes prepubertal male Wistar rats. Prepubertal rats (25-28 days old), weighing between 50-60 g were randomly divided into three treatment groups (B, C and D) control (A) ten each. Group A received distilled water while Groups B, C, D respectively given daily dose 50 mg/kg, 100 200 mg/kg dissolved in for 14 by gav...

This study aims to determine the 21st-century competencies of higher education students on verge digital transformation and their readiness for e-learning reveal relationship between these two variables. Having been carried out by using single relational screening models, this was conducted with 2100 attending participating in research voluntarily. E-Learning Readiness Scale consisting 33 items...

and glucocorticoid excretory responses to alpha 1-24 ACTH (Cortrosyn) in sodium-deplctcd normal man. J Clin Endocrinol Mctab 36: 30-35, 1973 14. Sncdccor GW. Cochran WG Statistical Methods, ed 6. Ames, Iowa State University Press, 1969, p 246 15. Dunnett CW: New tables for multiple comparisons with a control. Biometrics 20: 482-491, 1964 16 Laragh JH: Vasoconstnction-volume analysis for underst...

This paper discusses multiple testing procedures in dose-response clinical trials with primary and secondary endpoints. A general gatekeeping framework for constructing multiple tests is proposed, which extends the Dunnett test [Journal of the American Statistical Association 1955; 50: 1096-1121] and Bonferroni-based gatekeeping tests developed by Dmitrienko et al. [Statistics in Medicine 2003;...

A general multistage (stepwise) procedure is proposed for dealing with arbitrary gatekeeping problems including parallel and serial gatekeeping. The procedure is very simple to implement since it does not require the application of the closed testing principle and the consequent need to test all nonempty intersections of hypotheses. It is based on the idea of carrying forward the Type I error r...

Brown-Grant, K., Exley, D. & Naftolin, F. (1970) J. Endocrinol. 48, 295-296 Dunnett, C. W. (1964) Biomerrics 20,482-491 Freshney, R . I. & Paul, J. (1970) Biochim. Biophys. A r f a 220, 594-601 Held, H. & Przerwa, M. (1976) Eur. J. Clin. Invest. 6, 41 1-413 Kennedy, G. Y. (1970) Comp. Biochem. Physiol. 36,21-36 Margolis, F. L. (1971) Arch. Biochem. Biopliys. 145, 373-381 Moore, M. R., Beattie, ...