PURPOSE OF REVIEW Descemet's stripping with automated endothelial keratoplasty (DSAEK) has recently become the preferred surgical procedure replacing penetrating keratoplasty (PKP) for corneal endothelial disorders. However, DSAEK may also be associated with postprocedure intraocular pressure elevation and secondary glaucoma, and presents unique surgical challenges in patients with preexisting ...

OBJECTIVE To compare the 3-year incidence of de novo ocular hypertension (OHT) after Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK). For DSAEK, to evaluate predictors for OHT and 2-year outcomes after OHT development. METHODS This was a review of the prospective Singapore Corneal Transplant Study at a single tertiary referral center. Consecutiv...

PURPOSE To compare posterior corneal curvature in the fellow eye of the same patients after Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS This retrospective, case series comparative study included consecutive patients who underwent DSAEK in one eye and DMEK in the fellow eye. Each eye underwent corneal evaluation w...

OBJECTIVE To conduct a systematic review of the efficacy/effectiveness, safety and cost of Descemet's stripping automated endothelial keratoplasty (DSAEK) technique in patients with corneal endothelial failure. METHODS Comprehensive literature search conducted in the main biomedical databases from January-May 2012. RESULTS Following a critical perusal of the total of 485 abstracts retrieved...

PURPOSE One difficulty with Descemet's stripping automated endothelial keratoplasty (DSAEK) is air management during surgery and donor endothelial lamella centering. We evaluated the no-touch technique for donor centering and the use of a newly developed DSAEK donor adjuster. METHODS We evaluated the records of 12 consecutive patients (mean age 75.3 years) with bullous keratopathy who had und...

AIM To evaluate the efficacy of a technical modification to reduce the incidence of traumatic cataract induced by Descemet stripping automated endothelial keratoplasty (DSAEK) performed in phakic eyes. METHODS A retrospective cohort study. The records of all patients with a clear crystalline lens and endothelial failure that underwent modified DSAEK at our insitution were reviewed. In this mo...

BACKGROUND The purpose of this study was to compare endothelial cell counts after Descemet's stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty in Asian eyes. METHODS This was a retrospective study of patients from our prospective Singapore Corneal Transplant Study cohort who received corneal transplantation in 2006-2008. We compared eyes that underwent DSAEK or...

Purpose To determine the factors that influence the endothelial cell density (ECD) of donor grafts after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods This retrospective, interventional case series comprised 77 eyes of 64 patients who underwent DSAEK. Confocal microscopy was performed at the final follow-up examination to evaluate the endothelial cell count, cell morp...

Purpose To evaluate the association between endothelial cell density (ECD) after Descemet's stripping automated endothelial keratoplasty (DSAEK) and preoperative cytokine levels in the aqueous humor (AqH). Methods This prospective consecutive case series included 97 consecutive patients who underwent DSAEK (64 eyes) or cataract surgery (33 eyes). AqH samples were collected at the beginning of...

343 The emergence of endothelial keratoplasty (EK) represents the beginning of a new era in the treatment of corneal endothelial disorders which continues to evolve. Fifteen years ago we were performing penetrating keratoplasty for Fuchs’ dystrophy and bullous keratopathy but nowadays we are performing selective replacement of the diseased endothelial layer. In recent years two techniques of EK...