background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

background and objective: implementation of standard methods for accurate detection of bacteria, correct antibiotic susceptibility testing and effective treatment of bacterial infections play important roles in development of public health and prevention of drug resistance. this study aimed to detect bacteria using standard methods and compare the results with the results obtained in teaching h...

Pyrazinamide is an important drug used in anti tubercular treatment which helps in killing old and semi dormant bacilli which are not metabolically active. Drug susceptibility tests are routinely performed before initiating multidrug drug resistant tuberculosis treatment. However, many Tuberculosis laboratories do not undertake drug susceptibility testing of Pyrazinamide as it is difficult to p...

background: metronidazole, a 5-nitroimidazole derivative, is the main antitrich­omonal agent of  choice   for   treatment  of t richomoniasis . since 1962, s ome cases of treatment failure with metronidazole have been reported and recently drug re­sistance is now on the rise in the world. this study was aimed to determine current susceptibility of iranian isolates of trichomonas vaginalis to me...

voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. it is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. voriconazole shows a propotional increase in an area under the plasma concentration-time curve (auc), with increasing dose. plasma protein binding of...

tuberculosis remains a major public health problem in both developing and developed countries. drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (tb) control programs. information about the susceptibility pattern of mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to tb control. the objectives of the study...

A rapid drug susceptibility test to measure the susceptibility of Mycobacterium tuberculosis to isoniazid (INH) and rifampin (RIF) using clinical isolates and a newly defined mycolic acid index (MAI) was evaluated. A total of 200 clinical isolates of M. tuberculosis were tested for susceptibility or resistance to INH and RIF by the MAI susceptibility and indirect-proportion methods. Overall, th...