cockroaches were collected from hospitals, houses and poultry sheds in various parts of isfahan (iran) and identified to species. in total, seven species of cockroaches in seven genera were identified: blatta lateralis, polyphaga aegyptiaca, arenivaga roseni and parcoblatta spp. three species periplaneta americana, blattella germanica and supella longipalpa (blattidae and blattellidae) were mor...

background: multi drug resistant (mdr) pseudomonas and acinetobacter species are defined as resistant to at least three classes of antibiotics. most studies have demonstrated that mdr gram negative infections convey increased mortality and morbidity. case: an 11-year –old girl was admitted to pediatric burns unit with burn injury of approximately 68% total body surface area (tbsa). discussion: ...

Seventy-five percent of lung adenocarcinomas with epidermal growth factor receptor (EGFR) mutations respond to treatment with the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib; however, drug-resistant tumors eventually emerge. In 60% of cases, resistant tumors carry a secondary mutation in EGFR (T790M), amplification of MET, or both. Here, we describe the establishment of erlotinib ...

Multidrug resistance (MDR) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. Nevertheless, in most drug resistant cell lines and cancer patients up-regulation of ABC-transporter genes such as MDR associated Protein (MRP1) gene could be at the basis of the drug resistance phenotype. We aimed to decre...

Her-2/neu(+) tumor cells refractory to antibody or receptor tyrosine kinase inhibitors are emerging in treated patients. To investigate if drug resistant tumors can be controlled by active vaccination, gefitinib and antibody sensitivity of four neu(+) BALB/c mouse mammary tumor lines were compared. Significant differences in cell proliferation and Akt phosphorylation were observed. Treatment-in...

background hospital patients who are nasal carriers of methicillin-resistant staphylococcus aureus (mrsa) are a high-risk potential threat to themselves and other hospitalized patients. the high antibiotic resistance of these isolates renders the treatment of related infections difficult. objectives the present study, for the first time investigated the prevalence of mrsa isolates in nasal carr...

determination of drug resistance rate, as a new major problem in patients with typhoid fever is inevitable for treatment of the disease. in a cross-sectional study, during march 1994 till february 1995, a total of 39 patients with typhoid fever admitted to dept. of infections diseases, emam khomeini hospital, and were examined for the rate of resistance to routine drugs usually used for treatme...