BACKGROUND Drug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system. Epidemiological data related to drug hypersensitivity reactions in our country are scarce. OBJECTIVE To determine the prevalence of drug hypersensitivity in a group of young adults, as well as to identi...

Background: Drug-induced hypersensitivity syndrome (DIHS) can be associated with cytomegalovirus (CMV) infection, besides induced by drugs. We report a case of DIHS prolonged atypical clinical features and vasculitis precipitated drug allergy, CMV, other viral infections.

Drug-induced hypersensitivity reactions encompass a variety of different clinical phenotypes ranging from harmless rashes to fatal reactions. They can be classified into allergic (i.e. drug allergy) and non-allergic hypersensitivity). Drug allergies in turn either antibody (e.g. IgE) or T cell-mediated. One the diagnostic tools for vitro detection allergy is lymphocyte transformation test (LTT)...

Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark features of this syndrome are: Fever, rash and lymphadenopathy. The epoxide hydrolase en...

OBJECTIVE To evaluate the prevalence of drug hypersensitivity, clinical manifestations, type of drugs involved, severity, and patients demographic data. STUDY DESIGN A cross-sectional descriptive study. MATERIAL AND METHOD The study was performed from January 1st, 2008 to December 31th, 2008 at Phramongkutklao Hospital. Data were collected from Pharmaceutical Department, Dermatology Unit, D...

Drug hypersensitivity is a common and complicated problem in clinical practice. The clinical picture of drug hypersensitivity is very heterogeneous, encompassing such distinct diseases as morbilliform or bullous exanthema, urticaria, anaphylaxis, blood cell dyscrasia, fever, interstitial lung disease, hepatitis, nephritis, and various forms of autoimmune diseases. Drug hypersensitivity has take...

BACKGROUND The liver is the most commonly involved internal organ in drug-induced systemic hypersensitivity. However, data obtained from these patients have yet to be analyzed in depth with respect to liver injury. METHODS The medical records of 136 patients who developed delayed-type drug hypersensitivity were reviewed at a tertiary referral hospital. Culprit drugs, the pattern and degree of...

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmaco...