introduction: interaction between drugs represents a major clinical concern for health care professionals and their patients. patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin  concurrently. the aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. according to t...

objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...

drug prescription errors are a common cause of adverse incidents and may lead to adverse outcomes, sometimes in subtle ways, being compounded by circumstances or further errors. therefore, it is important that veterinarians issue the correct drug at the correct dose. using two or more prescribed drugs may lead to drug interactions. some drug interactions are very harmful and may have potential ...

Background: Drug-drug Interaction (DDI) among the elderly is one of the major healthcare challenges worldwide. The present study assessed the rates of DDI and inappropriate drug prescription among the elderly in Kashan City, Iran.  Methods: This descriptive-analytical study was designed, conducted, and reported according to the guideline of Strengthening the Reporting of Observational Studies ...

in the near future, design of a new generation of drugs targeting proteins will be required. considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. so far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. in these studies, use of spectroscopic method...

acriflavine (3,6-diaminoacridine) is an anticeptic drug developed in 1912. previous research has focused on investigation of the intercalating features of acriflavine, but little is known about its interaction with proteins. drug-receptor interaction is of major interest in clinical science. the aim of the present study was to evaluate the ability of acriflavine to induce alterations in conform...