Drug-combination analysis is discussed and demonstrated. Suppose we have a set of drugs (or other treatments which we misclassify as “drugs” for the purpose of our analysis.) These drugs are supposed to be treatments for some disease, e.g., HIV infection. Our goal is to assess whether, and to what extent, treatment with a particular combination of these drugs is more or less effective than some...

SUMMARY Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug research. In this work, we present the Drug Combination Database, wi...

Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...

extended-release matrix tablets of diltiazem hydrochloride (dtz) were prepared using waxy materials alone or in combination with kollidon sr. matrix waxy materials were carnauba wax (cw), bees wax (bw), cetyl alcohol (ca) and glyceryl monostearate (gms). dissolution studies were carried out by using a six stations usp xxii type 1 apparatus. the in vitro drug release study was done in 1000 ml ph...

the development of combination therapy is a coherent approach in severe pain treatment. the present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. therefore, three groups of male mice received either pregabalin (1 to 400 mg/kg), tramadol (10 to 80 mg/kg) or their combination intraperitoneally. then latency time, maximum...