Peels are major byproducts of the juice processing industry. Citrus peels composed two tissues, namely flavedo (outer layer) and albedo (inner layer). Here, were obtained from peel grapefruit cv. ‘Star ruby’, lemon ‘Akragas’, sweet orange cvs. ‘Tarocco’, ‘Sanguinello’ ‘Moro’. Freeze dried investigated for their functional properties, subjected to enzyme-assisted extraction with pectinase cellul...

The aim of this investigation was to compare the influence of naringin versus red grapefruit juice on plasma lipid levels and plasma antioxidant activity in rats fed cholesterol-containing and cholesterol-free diets. The antioxidant activity of a correlated quantity of red grapefruit juice was higher than that of naringin. Forty-two male Wistar rats were randomly divided into six groups of 7 na...

Influence of grapefruit juice intake on aflatoxin B1 (AFB1)-induced liver DNA damage was examined using a Comet assay in F344 rats given 5 mg/kg AFB1 by gavage. Rats allowed free access to grapefruit juice for 5 days prior to AFB1 administration resulted in clearly reduced DNA damage in liver, to 65% of the level in rats that did not receive grapefruit juice. Furthermore, rats treated with grap...

The effect of the intake of 200 g of grapefruit pulp (corresponding to one grapefruit) on the pharmacokinetics of the calcium antagonists nifedipine (NF) and nisoldipine (NS) were investigated in 8 healthy Japanese male volunteers. A crossover design was used for the study: group I did not ingest any grapefruit (control group); group II ingested grapefruit 1 h after drug administration; and gro...

This study measured the effect of media exposure on grapefruit/grapefruit juice consumption changes, in particular grapefruit-medicine interaction. Respondents' attitudes about health news on television and the internet were measured to account for consumers exposed versus not exposed to such information. Results of a sample selection model show that consumer attitudes toward health news were s...

4. Rouse, A. H., C. D. Atkins and R. L. Huggart. 1954. Effect of pulp quantity on chemical and physi cal properties of citrus juices and concentrates. Food Technol. 8: 431-435. 5. U. S. Dept. Agriculture. U. S. standards for grades of canned citrus juices and concentrates. Agricultural Marketing Service, Washington, D. C: (a) Frozen concentrated grapefruit juice, Dec. 1951; (b) Frozen concentra...

background: recently grapefruit juice is known to enhance the bioavailability of several clinically important drugs such as nifedipine, terfenadine, cyclosporine, ethinylestradiole, midazolam, and triazolam. cyclosporine is an immunosuppressive agent that used in transplantation for preventation of chronic rejection. grapefruit increase in cmax and auc of drug mediated by suppression of cyp3a4 ...

Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index. Pro...

A clinical study was performed in eight healthy volunteers to investigate the effect of various timing of grapefruit juice intake on nisoldipine pharmacokinetics and pharmacodynamics, and to validate our pharmacokinetic model. The subjects were given 10 mg oral nisoldipine with water (control), or 5 mg oral nisoldipine with 200 mL grapefruit juice (G0) or with water at 14 (G14), 38 (G38), 72 (G...