Patients with schizophrenia (SZ) previously demonstrated specific deficits in an executive function known as goal maintenance, associated with reduced middle frontal gyrus (MFG) activity. This study aimed to validate a new tool-the Dot Pattern Expectancy (DPX) task-developed to facilitate multisite imaging studies of goal maintenance deficits in SZ or other disorders. Additionally, it sought to...

BACKGROUND Future cancer immunotherapies will combine multiple treatments to generate functional immune responses to cancer antigens through synergistic, multi-modal mechanisms. In this study we explored the combination of three distinct immunotherapies: a class I restricted peptide-based cancer vaccine, metronomic cyclophosphamide (mCPA) and anti-PD-1 treatment in a murine tumor model expressi...

Exposure to certain xenochemicals can alter the catalytic activity of the major drug-metabolizing enzyme, CYP3A4, either by enhancing expression of this cytochrome P450 or inhibiting its activity. Such alterations can result in adverse consequences stemming from drug-drug interactions. A simplified and reliable tool for detecting the ability of candidate drugs to alter CYP3A4 levels or inhibit ...

Research in schizophrenia has increasingly focused on incorporating measures from cognitive neuroscience, but little is known about their psychometric characteristics. Here, we extend prior research by reporting on temporal stability, as well as age and sex effects, for cognitive neuroscience paradigms optimized as part of the Cognitive Neuroscience Test Reliability and Clinical applications fo...

Introduction: Mounting is the final stage in histologically preparing a slide and creates permanent bond between coverslip slide, preventing breakage, air drying artefacts, stain fading. Materials & methods: In this study, fifty slides were prepared, twenty-five of which mounted using DPX twenty five cyanoacrylate adhesive. The assessed for clarity nuclear cytoplasmic details, adhesion pres...

DNA-protein cross-links (DPXs) in fish erythrocytes represent a potential biomarker for exposure to metal cations, such as hexavalent chromium (Cr[VI]) and divalent nickel (Ni[II]). Species-specific sensitivities to DPX formation were studied by coexposure of juvenile specimens of rainbow trout, hybrid bluegill, and channel catfish to waterborne metals, such as Cr(VI) and Ni(II). In a species c...

Guanine nucleotides, divalent cations, and sodium differentially regulate agonist and antagonist binding to adenosine A1 receptors in brain membranes. Guanine nucleotides decrease the binding of the adenosine A1 receptor agonist [3H]N6-cyclohexyladenosine ([3H]CHA) to guinea pig and bovine brain membranes by about 50% at 1--3 microM, while not affecting binding of the antagonist [3H]1,3-diethyl...

infection status of soybean field to tobacco ringspot virus (trsv) in golestan provincein order to serological detection of tobacco ringspot virus in soybean fields of golestan province, during 2008 growing season, infected samples of dpx, gorgan3, williams, pershing and jk cultivars with leaf malformation, stunting, necrosis and terminal bud blight symptoms, were collected and tested by enzyme...

INTRODUCTION The administration of dopexamine may constitute a therapeutical option to improve hepatosplanchnic perfusion in sepsis. In order to verify this hypothesis, we administered dopexamine in an experimental sepsis model in rats. METHODS This prospective, randomized, controlled laboratory study was conducted in 42 Wistar rats. The animals were divided into 3 groups. Group 1 (CON group)...