In the present study a simple, rapid, sensitive, and cost-effective stability indicating UV- spectrophotometric method was developed of doxycycline hyclate in bulk form validated as per ICH guidelines. The stability-indicating based on forced degradation reactions drug under different ICH-prescribed stress conditions like acid, alkali, neutral, oxidation, thermal, photolysis. absorption maximum...

The histophagous ciliate Philasterides dicentrarchi causes fatal scuticociliatosis in farmed turbot Scophthalmus maximus and sea bass Dicentrarchus labrax. The present study screened 52 candidate antiprotozoals for activity against this pathogen in vitro. Of these compounds, 14 were effective (i.e. killed all ciliates within a 24 h assay period). In descending order of efficacy (minimum lethal ...

OBJECTIVES To characterize the mechanical and biological properties of a resin-modified glass ionomer cement (RMGIC) containing doxycycline hyclate. METHODS The antibacterial effect of RMGIC containing 1.5, 3.0 and 4.5% doxycycline hyclate was assessed using two experiments - agar diffusion test for 24h and biofilm assay for 24h and 7 days - against some cariogenic bacteria. Briefly, base lay...

Canine ehrlichiosis is caused by the bacterium Ehrlichia canis and is characterized by a systemic febrile disease of unknown pathogenesis. This study evaluated the expression of cytokines TNF-α, IL-10, IFN-γ, in splenic cells and blood leukocytes during the acute phase of ehrlichiosis and after treatment with doxycycline hyclate in dogs experimentally infected with the E. canis Jaboticabal stra...

OBJECTIVES Locally used doxycycline has been shown to concentrate in crevicular fluid and demonstrates a wide spectrum of activity against the periodontal pathogens. The aim of the present clinical study was to evaluate the efficacy of doxycyline hyclate 10% as an adjunct to scaling and root planing in the treatment of chronic periodontitis. MATERIAL AND METHODS 60 systemically healthy, chron...

PURPOSE The aim of the study was the clinical assessment of the periodontium in patients with aggressive periodontitis (AP) after treatment with doxycycline hyclate. Moreover, an attempt was made to evaluate the effect of the treatment on the salivary concentrations of beta-glucuronidase, HEX, HEX A and HEX B in AP patients. MATERIAL AND METHODS Sixteen patients with aggressive periodontitis,...

in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. a...

AIM The aim of this study was to evaluate and compare the efficacy of subgingivally delivered 10% doxycycline hyclate and xanthan based chlorhexidine gels when used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. METHODS AND MATERIALS A randomized, controlled, single center study was conducted involving 90 sites in 30 patients suffering from moderate...