Patients with breast or ovarian cancer have not benefited from improved efficacy pegylated liposomal doxorubicin relative to free drug, likely due the limited extent of enhanced permeability and retention (EPR) effect, further compromising drug bioavailability in tumor. Herein it is hypothesized that targeting nucleolin overexpressed tumor endothelial cells (readily accessible vascular compartm...

In article 2200097, J. Wang, D. Li, Q. Xu, H. C. Liang, X. Zhang, S.-B. A. Chen, and N. Jiang prepare platinum/mesoporous silica/amorphous calcium phosphate core-shell nanostructures (Pt@mSiO2@CaP), loaded by doxorubicin hydrochloride (DOX), for synergistic chemo- photothermal therapy. The DOX-Pt@mSiO2@CaP is internalized in the lysosomes of U-87 MG cells efficiently releases DOX cells. under n...

OBJECTIVE To investigate whether the mechanism for the reversal of ABCG2 (also known as ABCP, MXR, and BCRP)-mediated drug resistance by imatinib mesylate (Gleevec, STI571; Novartis Pharmaceuticals Corp, East Hanover, New Jersey) is caused by the downregulation of Akt kinase. The adenosine triphosphatase-binding cassette protein ABCG2 has been suggested to be involved in the resistance against ...

AIM The new formulation of doxorubicin on the base of phospholipid nanoparticles (particle size <30 nm) is elaborated in the Institute of Biomedical Chemistry (Russian Academy of Medical Sciences) on the base of plant phospholipids. The aim of study is to investigate an antitumor effect of this nanoformulation in mice with two cancer models with various sensitivity to chemotherapy — lymphoid ma...

Background. The development of a microcomputer-based device permits quick, simple, and noninvasive quantification of the respiratory sinus arrhythmia (RSA) during quiet breathing. Methods and Results. We prospectively and serially measured the radionuclide left ventricular ejection fraction and the RSA amplitude in 34 cancer patients receiving up to nine monthly bolus treatments with doxorubici...

Colorectal cancer (CC) is an important human malignancy with high related death worldwide. The chemotherapy using doxorubicin hydrochloride one of the most common therapeutic methods. However, drug resistance lowers treatment efficacy in CC patients. combination therapies seem to be more promising by taking advantage synergistic effects. present study aimed evaluate a new strategy enhance antic...