beta-emitting 166Ho (t1/2 = 26.78 hours, E(beta)max = 1.8 MeV) complexed with the phosphonic acid chelator, 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic acid) (DOTMP) at a ligand-to-metal ratio of 1.5:1 binds to bone. This radioactive complex is a marrow-ablating radiopharmaceutical that appears useful for preparation of bone marrow (BM) transplant recipients without the m...

1 2 3 4 5 6 7 8 Quantitative and Functional Interrogation of Parent-of-Origin 9 Allelic Expression Biases in the Brain 10 11 Julio D. Perez, Nimrod D. Rubinstein, Daniel E. Fernandez, Stephen W. Santoro, 12 Leigh A. Needleman, Olivia Ho-Shing, John J Choi, Mariela Zirlinger, Shau-Kwaun 13 Chen, Jun S. Liu, Catherine Dulac* 14 Department of Molecular and Cellular Biology, Harvard University, How...

Micelles derived from poly(ε-caprolactone) (PCL) poly(ethylene glycol)(PEG) diblock copolymers (HO-PCLn-b-PEG32-RX, R = -O(CH2)3S(CH2)2-; X = -CO2(-), -SO3(-), -NH3(+)) show corona charge selective degradation catalyzed by P. cepacia lipase isoforms.

bone is the third most common site of metastatic disease. bone pain is the major source of morbidity associated bone metastasis. bone-seeking radiopharma- ceuticals have been applied for many years. the ability to simultaneously treat multiple sites of disease with a more probable therapeutic effect in earlier phases of metastatic disease is one of the advantages of radiopharmaceuticals. 175yb ...

Abstract The structural and bonding properties of Bi Ac complexes with cyclen-based chelating ligands have been studied using relativistic DFT calculations in conjunction TZ2P all-electron basis sets. Besides the parent cyclen ligand, study has covered its extensions pyridine-type (L py ), carboxylate (DOTA, DOTPA), picolinate (MeDO2PA) phosphonate (DOTMP) pendant arms. effect ring size probed ...

OBJECTIVE : To evaluate functional outcomes of patients submit-ted to proximal row carpectomy for the treatment of wrist arthri-tis. METHODS : This is a retrospective study using wrist motion and grip strenght of patients diagnosed with Kienböck disease and scaphoid non-union surgically treated by this technique. RESULTS : Eleven patients with 2-year follow-up were evaluated. Wrist motion (...

Seung-Ho Baek, Oh-Young Kim, Chang-Keun Kim, Byeong-Hoon Cho* Department of Conservative Dentistry & Dental Research Institute, College of Dentistry, Seoul National University, Department of Polymer Science and Engineering, Dankook University, Department of Chemical Engineering, Chung-ang University Influence of the curing time for the adhesive on the oxygen-inhibited layer thickness and the sh...