background: new treatment modalities are developed with the aim of escalating tumor absorbed dose and simultaneously sparing the normal structures. the use of nanotechnology in cancer treatment offers some possibilities including destroying cancer tumors with minimal damage to healthy tissues. zinc oxide nanoparticles (zno nps) are wide band gap semiconductors and seem to have a good effect on ...

INTRODUCTION Gold nanoparticles have been used as radiation dose enhancing materials in recent investigations. In the current study, dose enhancement effect of gold nanoparticles on tumor cells was evaluated using Monte Carlo (MC) simulation. METHODS We used MCNPX code for MC modeling in the current study. A water phantom and a tumor region with a size of 1×1×1 cm3 loaded with gold nanopartic...

Background: New treatment modalities are developed with the aim of escalating tumor absorbed dose and simultaneously sparing the normal structures. The use of nanotechnology in cancer treatment offers some possibilities including destroying cancer tumors with minimal damage to healthy tissues. Zinc Oxide nanoparticles (ZnO NPs) are wide band gap semiconductors and seem to have a good effect on ...

introduction in this study, we aimed to calculate dose enhancement factor (def) for gold (au) and iron (fe) nanoparticles (nps) in brachytherapy and teletherapy, using monte carlo (mc) method. materials and methods in this study, a new algorithm was introduced to calculate dose enhancement by aunps and fenps for iridium-192 (ir-192) brachytherapy and cobalt-60 (co-60) teletherapy sources, using...

BACKGROUND In neutron interaction with matter and reduction of neutron energy due to multiple scatterings to the thermal energy range, increasing the probability of thermal neutron capture by neutron captures makes dose enhancement in the tumors loaded with these materials. OBJECTIVE The purpose of this study is to evaluate dose distribution in the presence of 10B, 157Gd and 33S neutron captu...

Introduction: Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. There is increasing evidence that combining radiation therapy with a radiosensitizer can enhance the efficiency of this treatment modality. A radiosensitizer preferably enhances dose at the site of tumor and increases discrimination between tumor and normal surrounding tissue...

Introduction In this study, we aimed to calculate dose enhancement factor (DEF) for gold (Au) and iron (Fe) nanoparticles (NPs) in brachytherapy and teletherapy, using Monte Carlo (MC) method. Materials and Methods In this study, a new algorithm was introduced to calculate dose enhancement by AuNPs and FeNPs for Iridium-192 (Ir-192) brachytherapy and Cobalt-60 (Co-60) teletherapy sources, using...

Objective(s): In this study we evaluate the impact of the different aspects of Gold Nano-Particles (GNPs) on the target absorptive Dose Enhancement Factor (DEF) during external targeted radiotherapy with photon beams ranging from kilovolt to megavolt energies using Monte Carlo simulation. Methods: We have simulated the interaction of photon beams wi...

PURPOSE Bombarding high-Z material with x-ray radiation releases Auger electrons and Coster-Kronig electrons, along with deeper penetrating fluorescent x-rays and photoelectrons. The Auger and Coster-Kronig electron penetration distance is on the order of nanometers to micrometers in water or tissue, creating a large dose enhancement accompanied by a RBE greater than 1 at the cellular level. Th...

background: radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. material and methods: in this study...