Deoxynivalenol (DON) is a common Fusarium toxin in poultry feed. Chickens are more resistant to the adverse impacts of deoxynivalenol (DON) compared to other species. In general, the acute form of DON mycotoxicosis rarely occurs in poultry flocks under normal conditions. However, if diets contain low levels of DON (less than 5 mg DON/kg diet), lower productivity, impaired immunity and higher su...

dissolved organic nitrogen (don) can react with disinfectants to produce numerous disinfectionbyproducts (dbps), particularly nitrogen-containing dbps (n-dbps), and produce serious adverse effectson public health. widely used biological processes in drinking water treatment can increase don in effluents,and enhance these ill effects. this study investigated don in a full-scale two-stage ozonati...

Two experiments were conducted to characterize the progression of deoxynivalenol (DON)-induced growth suppression and to investigate algae-modified montmorillonite clay (AMMC) as a means to alleviate the effects of DON in nursery pigs. In both experiments, naturally DON-contaminated wheat was used to produce diets with desired DON levels. In Exp. 1, 280 barrows and gilts (10.0 ± 0.2 kg BW) were...

[1] Storm event patterns of dissolved organic nitrogen (DON) were studied for multiple events across four catchments (1.6–696 ha) in a forested, glaciated watershed in western New York State. Highest concentrations of DON in the watershed were recorded for litter leachate followed by throughfall. Storm event concentrations of DON consistently peaked at or before peak discharge while dissolved o...

Co-occurrence of deoxynivalenol (DON) with other DON derivatives/metabolites and other Fusarium toxins, including zearalenone, nivalenol and as well as other mycotoxins (e.g. fumonisins) is frequently observed in food and feed. DON-3beta-glucopyranoside (DON-3-glucoside) was described as detoxification product of DON in wheat. This mycotoxin conjugate was observed in maize, barley, malt, beer a...

Two experiments were conducted to evaluate potential detoxifying agents on growth of nursery pigs fed deoxynivalenol (DON)-contaminated diets. Naturally DON-contaminated wheat (6 mg/kg) was used to achieve desired DON levels. In a 21-d study, 238 pigs (13.4 ± 1.8 kg BW) were used in a completely randomized design with a 2 × 2 + 1 factorial arrangement. Diets were: 1) Positive control (PC; < 0.5...

Based on prior observations that deoxynivalenol (DON) toxicity is sex-dependent, we compared metabolism and clearance of this toxin in male and female mice. Following intraperitoneal challenge with 1 mg/kg bw DON, the dose used in the aforementioned toxicity study, ELISA and LC-MS/MS analyses revealed that by 24 h, most DON and DON metabolites were excreted via urine (49-86%) as compared to fec...

BACKGROUND Clinical significance of delayed-onset neutropenia (DON) after autologous hematopoietic stem-cell transplantation (ASCT) has not been well described. We conducted a retrospective cohort study to examine risk factors and clinical impact of DON. DESIGN AND METHODS Subjects were consecutive 108 patients with B-cell lymphoma receiving ASCT. We defined DON as absolute neutrophil counts ...