نتایج جستجو برای: dominant genes

تعداد نتایج: 546962  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Victor M Miller Haibin Xia Ginger L Marrs Cynthia M Gouvion Gloria Lee Beverly L Davidson Henry L Paulson

Small interfering RNA (siRNA) holds therapeutic promise for silencing dominantly acting disease genes, particularly if mutant alleles can be targeted selectively. In mammalian cell models we demonstrate that allele-specific silencing of disease genes with siRNA can be achieved by targeting either a linked single-nucleotide polymorphism (SNP) or the disease mutation directly. For a polyglutamine...

Journal: :The Journal of Experimental Medicine 1978
M Hurme P R Chandler C M Hetherington E Simpson

The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems that H-2-retricted anti-H-Y cytotoxic ...

Journal: :Genetics 1979
P J Avery W G Hill

The influence of small population size (N) on the genetic variance within and between randomly bred unselected lines, with selfing permitted, is investigated for a model of a quantitative trait determined by linked genes that show dominance within loci but are additive over loci. Formulae for within-line variance include terms in linkage disequilibrum, which occurs by chance in the lines and th...

رحیم هنرنژاد, , مرداویج شعاعی دیلمی, ,

The results of diallel analysis of 7 parents and 21 F2 progenies of Burley tobacco cultivars, which were transplanted in 2002 as RCBD with 3 replications in the Tobacco Research Center, Rasht, Iran, showed significant genetic differences among genotypes and high GCA and SCA for most of the traits. Therefore the role of additive and non-additive (dominant) effects of genes on the formation of th...

E. Khosravi, M. Khodambashi Sh. Mohammadi

Monogenic inheritance and linkage among four morphological traits of lentil were established on the basis of F1 observations and analysis of 204 F2 plants in a cross for development of pubescence on peduncle, 228 F2 plants in a cross for tendril formation, 574 F2 plants in 5 crosses for flower numbers per peduncle and 464 F2 plants in 4 crosses for flower color under field conditions. Developme...

ژورنال: علوم آب و خاک 2004
رحیم هنرنژاد, , مرداویج شعاعی دیلمی, ,

The results of diallel analysis of 7 parents and 21 F2 progenies of Burley tobacco cultivars, which were transplanted in 2002 as RCBD with 3 replications in the Tobacco Research Center, Rasht, Iran, showed significant genetic differences among genotypes and high GCA and SCA for most of the traits. Therefore the role of additive and non-additive (dominant) effects of genes on the formation of th...

Journal: :acta medica iranica 0
masoumeh mohebi farabi eye research center, farabi eye hospital, tehran university of medical sciences, tehran, iran. abolfazl akbari colorectal research center, iran university of medical sciences, tehran, iran. nahid babaei department of molecular cell biology and genetics, bushehr branch, islamic azad university, bushehr, iran. abdolrahim sadeghi department of biochemistry and genetics, molecular and medicine research center, arak university of medical sciences, arak, iran. mansour heidari department of molecular cell biology and genetics, bushehr branch, islamic azad university, bushehr, iran. and experimental medicine research center, tehran university of medical sciences, tehran, iran. and department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran.

autosomal dominant congenital cataract (adcc) is the most common form of inherited cataracts and accounts for one-third of congenital cataracts. heterozygous null mutations in the crystallin genes are the major cause of the adcc. this study aims to detect the mutational spectrum of four crystallin genes, cryba1/a3 , crybb1 , crybb2 and crygd in an iranian family. genomic dna was isolated from w...

Journal: :American journal of medical genetics 2000
P A Otto S R Maestrelli

Heterozygosity probabilities P(het) for relatives of isolated cases produced by incompletely penetrant autosomal dominant genes and recurrence risks for their offspring, R = P(het).K/2, where K is the penetrance value, have been calculated in the literature for some simple particular situations. Bayes theorem and elements from the theory of finite difference equations enabled us to derive the h...

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