نتایج جستجو برای: dominant gain
تعداد نتایج: 295026 فیلتر نتایج به سال:
It has been proposed that human telomerase RNA (hTR) interacts with dyskerin, prior to assembly of the telomerase holoenzyme. The direct interaction of dyskerin and hTR has not been demonstrated and is an experimentally challenging research problem because of difficulties in expressing and purifying dyskerin in quantities that are useful for biophysical analysis. By orthogonally labeling dysker...
Increasing the complexity of their models, p53s are stabilized either in order to function (wt p53) or due to the loss of function (mutant p53) with acquiring a mysterious prion-like ability to drive the normal p53 into the abnormal conformation to gain new functions. As already recognized, the loss of trans-activating function leads to a stabilization of mutant p53 because of the disappearance...
Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities
conclusions the dominant side scapula of asymptomatic racquet players showed increased external rotation and elevation as compared to the non-dominant side. also, reduced shoulder internal rotation, extension and adduction and gain in shoulder external rotation was observed on the dominant side of racquet players when compared to the control group. materials and methods 46 asymptomatic professi...
The Rho/Rho-kinase pathway in the nucleus tractus solitarii (NTS) of the brain stem contributes to blood pressure regulation. Activation of this pathway might be involved in the central nervous system mechanisms of hypertension. The aim of the present study was to determine whether baroreflex control of heart rate is altered by inhibition of Rho-kinase in the NTS. Adenovirus vectors encoding do...
خلاصه فارسی: به علت وجود مشکلات استفاده از داروهایی با نیمه عمر کوتاه که نیازمند تجویز چند دوز در طی یک روز می باشند، مانند فراموش کردن دریافت دوز دارو و ثابت نبودن سطح خونی و... ضرورت ساخت اشکال modified release واضح و مبرهن است. از میان راه های مختلف دارورسانی به بدن، راه خوراکی به علت مزایای ویژه خود همچنان از جایگاه مهمی در داروسازی برخوردار می باشد. اشکال دارویی متنوعی نیز این امکان را فر...
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