نتایج جستجو برای: dna repair gene

تعداد نتایج: 1565035  

Jamshid Ansari, Milad Pezeshki,

Background: Breast cancer is one of the most common worldwide malignancies among women. Biological data suggest that damage induced by endogenous and exogenous factors affects the integrity of DNA and associated with susceptibility to breast cancer. Single nucleotide polymorphisms (SNPs) in DNA repair genes can associated with differences in the repair efficiency of DNA damage and may affect br...

Journal: :RSC chemical biology 2023

Protein arginine methylation is a widespread post-translational modification (PTM) in eukaryotic cells. This chemical proteins functionally modulates diverse cellular processes from signal transduction, gene expression, DNA damage repair,...

Journal: :journal of cell and molecular research 0
jalal soltani raymond brandt gerard paul h. van heusden paul j. j. hooykaas

agrobacterium tumefaciens is capable to transfer genes across kingdoms. it can genetically transform not only plant cells, but also many other bacterial, algal, fungal, animal and human cells. this depends on the interactions among a variety of both agrobacterium and host genes. inside the host cell, rad52 which is involved in dna repair is a key gene determining integration of t-dna by homolog...

Armaghan Fard-Esfahani, Bahareh Ghanbarzadeh, Mina Majdi, Parinaz Saidi, Pezhman Fard-Esfahani, Reyhaneh Mohabati, Seyed Kazem Bidoki, Shima Fayaz,

Background: X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA repair gene and its non-synonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer development. Methods: A case-control study was conducted to investigate impact of three frequently studied polymorphisms (Arg194Trp, Arg280His and Arg3...

Journal: :iranian journal of basic medical sciences 0
saghar pahlavanneshan department of genetics, faculty of biological sciences, tarbiat modares university, tehran, iran amirhossein ahmadi department of genetics, faculty of biological sciences, tarbiat modares university, tehran, iran mohammadali boroumand tehran heart center, tehran university of medical sciences, tehran, iran saeed sadeghian tehran heart center, tehran university of medical sciences, tehran, iran mehrdad behmanesh department of genetics, faculty of biological sciences, tarbiat modares university, tehran, iran

objective(s): coronary artery disease (cad) is the leading cause of death in both male and female worldwide. the main cause of cad is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. x-ray repair cross-complementing protein 1 (xrcc1) as a ...

Armaghan Fard-Esfahani, Maryam Rahimi, Mohammad Hossein Modarressi, Pezhman Fard-Esfahani, Seyed Mohammad Akrami, Shima Fayaz,

Background: The aim of this study was to understand any association between differentiated thyroid carcinoma (DTC) and Ile3434Thr XRCC7 gene polymorphism (GenBank accession number: rs7830743). DTC is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. XRCC7 gene encodes a protein that functions in non-homologous end joining DNA repair pathway. Non-synony...

Journal: :Mutagenesis 2007
Filipe V Jacinto Manel Esteller

Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair genes. Hypermethylation of CpG islands in gene promoter regions is an important mechanism of gene inactivation in cancer. Many cellular pathways, including DNA repair, are inactivated by this type of epigenetic lesion, resulting in mutator pathways. In this review, we discuss the adv...

2005
Vilhelm A.Bohr

There is increasing interest in gene-specific repair studies. This aspect of DNA repair is currently under intense investigation and new laboratories are entering the field. The data are coming in rapidly and we are in the midst of exciting developments. Accordingly, it is premature to build extensive models of the regulation and biological importance of gene specific repair. The purpose of thi...

Journal: :iranian biomedical journal 0
مریم رحیمی maryam rahimi شیما فیاض shima fayaz ارمغان فرد اصفهانی armaghan fard-esfahani محمد حسین مدرسی mohammad hossein modarressi سید محمد اکرمی seyed mohammad akrami پژمان فرد اصفهانی pezhman fard-esfahani

background: the aim of this study was to understand any association between differentiated thyroid carcinoma (dtc) and ile3434thr xrcc7 gene polymorphism (genbank accession number: rs7830743). dtc is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. xrcc7 gene encodes a protein that functions in non-homologous end joining dna repair pathway. non-synony...

Journal: :Oligonucleotides 2006
Olga Igoucheva Vitali Alexeev Orlando Scharer Kyonggeun Yoon

Oligodeoxynucleotide (ODN)-mediated gene alteration was postulated to occur in two steps, DNA strand pairing and DNA repair. Once alignment has occurred through homologous strand pairing, a single mismatch is formed between an oligonucleotide and one of the target strands. Because of this mismatch, it has been suggested that proteins involved in a mismatch repair pathway (MMR) participate in th...

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