the transformation of biochemical information into a physical or chemical signal is the basic idea behind a biosensor. the efficient detection of charged biomolecules by biosensor with appropriate device has caught tremendous research interest in the present decade. the present work is related to the simulation study of the performance of a functionalized surface of a biologically sensitive fie...

Simple computation can be performed using the interactions between single-stranded molecules of DNA. These interactions are typically toehold-mediated strand displacement reactions in a well-mixed solution. We demonstrate that a DNA circuit with tethered reactants is a distributed system and show how it can be described as a stochastic Petri net. The system can be verified by mapping the Petri ...

DNA computing has recently gained intensive attention as an emerging field bridging the gap between computer science and biomolecular science. DNA based computing can be competitively used to simulate various computing models including Boolean circuits because of its potential to offer massive parallelism. In this paper we present a new DNA-based evaluation algorithm for a bounded fan-in circui...

This work describes the development of an integrated biosensor based on phototransistor integrated circuits (IC) for use in medical detection, DNA diagnostics, and gene mapping. The evaluation of various system components developed for an integrated biosensor microchip is discussed. Methods to develop a microarray of DNA probes on nitrocellulose substrate are discussed. The biochip device has s...

Based on the accurate identification of chemical structures as electric elements, we described charge transport mechanism in a DNA molecule by a stepwise LC oscillatory circuitry, in which every base pair is a capacitor, every phosphate bridge is an inductor, and every deoxyribose is a charge router. The circuit model agrees with established experimental evidence that has supported super-exchan...

UNLABELLED Alterations in DNA repair promote tumor development, but the impact on tumor progression is poorly understood. Here, discovery of a biochemical circuit linking hormone signaling to DNA repair and therapeutic resistance is reported. Findings show that androgen receptor (AR) activity is induced by DNA damage and promotes expression and activation of a gene expression program governing ...

A new model of DNA computation that is based on surface chemistry is studied. Such computations involve the manipulation of DNA strands that are immobilized on a surface, rather than in solution as in the work of Adleman. Surface-based chemistry has been a critical technology in many recent advances in biochemistry and ooers several advantages over solution-based chemistry, including simpliied ...

Abstract Background In this paper, a simple, enzyme-free, label-free fluorescence, high sensitivity logic gate hairpin aptasensor was developed for adenosine triphosphate (ATP) detection based on graphene oxide (GO) and PicoGreen dye. Methods Using single-strand deoxyribonucleic acid (DNA) as input signal fluorescence output signal, if DNA (DNA-L), (DNA-S), ATP were present at the same time, on...