M-currents are K+ currents generated by members of the KCNQ family of K+ channels (Wang et al., 1998). However, in some cells, M-like currents may be contaminated by members of other K+ channel gene families, such as the erg family (Meves et al., 1999; Selyanko et al., 1999). In the present experiments, we have used the acute expression of pore-defective mutants of KCNQ3 (DN-KCNQ3) and Merg1a (...

BACKGROUND Antibody-mediated hyperacute and acute graft rejection are major obstacles in achieving long-term graft survival in xenotransplantation. It is well documented that regulatory T (Treg) cells play a very important role in regulating immune responses to self and non-self antigens. Our previous studies have shown that TCRalphabeta+CD3+CD4-CD8- (double negative, DN)-Treg cells can suppres...

INTRODUCTION Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is available for rheumatoid arthritis (RA). We therefore focused on DN B cells in RA, studied...

Abstract This article proposes a re-examination of the phases construction and decoration at shrine ‘Abd al-Samad in Natanz demonstrates that core fabric elements architectural revetments are datable to Seljuq period ( 431-590/ 1040-1194), or slightly later. The structure was repurposed redecorated, including addition extensive lustre tiles stucco, for by Zayn al-Din al-Mastari early years four...

The integral circulant graph ICGn(D) has the vertex set Zn = {0, 1, 2, . , n? 1} and vertices a b are adjacent if gcd(a ? b, n) D, where D Dn, Dn {d : d | n, 1 < n}. Motivated by incorrect proof of previously published result, in this paper we characterize class graphs that strongly regular. More precisely, connected is regular only n composite m d} for some 2.

CONTEXT Subjects with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) often exhibit hypertriglyceridemia. The mechanism(s) of such an increase are poorly known. OBJECTIVE We investigated very low-density lipoprotein (VLDL)-Apo B 100 kinetics in T2DM subjects with and without DN, and in healthy controls. DESIGN Stable isotope (13)C-leucine infusion and modeling analysis of trac...

<b><i>Introduction:</i></b> Diabetic nephropathy (DN) remains a major cause of end-stage renal disease. The development novel biomarkers and early diagnosis DN are great clinical importance. goal this study was to identify hub genes with diagnostic potential for by weighted gene co-expression network analysis (WGCNA). <b><i>Methods:</i></b> Gene E...

The objective of the present study was to investigate the effects of β-conglycinin and soya isoflavones on diabetic nephropathy (DN). DN was induced by an intravenous injection of streptozotocin (25 mg/kg) in spontaneously hypertensive rats. DN rats were divided into a non-diabetic group (C, control group) and three DN groups (D, DN with control diet; B, DN+control diet with one-eighth of casei...

Histone deacetylases (HDACs) have been implicated in the pathogenesis of kidney diseases including diabetic nephropathy (DN); however, the mechanism is poorly understood. Wang et al. unravel the changes in expression of various HDACs in DN and demonstrate that HDAC4 specifically contributes to podocyte injury in DN. HDAC4 deacetylates STAT1 to suppress autophagy, an essential cellular process f...

Positive selection in the human immunodeficiency virus type 1 (HIV-1) env gene has been demonstrated by comparisons of the abundance of nonsynonymous (dn) and synonymous (ds) pairwise variability in the DNA sequence (Bonhoeffer, Holmes, and Nowak 1995; Seibert et al. 1995; Yamaguchi and Gojobori 1997). An increase in dn above the neutral expectation of dn # ds provides an unambiguous indication...