Demethyleneberberine (DMB) is an essential metabolite of Berberine (BBR) in vivo. Recent reports have revealed multiple novel therapeutic applications of BBR. However, the pharmacological activities of DMB remain to be elucidated. This study aimed to demonstrate the hepatoprotective and anti-fibrotic effects of DMB both in vitro and in vivo. Here we showed that DMB protects against thioacetamid...

It is shown that Streptococcus pneumoniae possesses a Ca2+ transporter, sensitive to the amiloride derivative 2',4'-dimethylbenzamil (DMB), which is essential for grown at high Ca(2+)-concentrations, and which mediates the triggering by Ca2+ of competence for genetic transformation in the exponential phase and autolysis in the late exponential phase. DMB inhibited both Ca2+ transport and the Ca...

Salmonella enterica subsp. sv. Typhimurium str. LT2 (hereafter S. Typhimurium) synthesizes adenosylcobalamin (AdoCbl, CoB12) de novo only under anoxic conditions, but it can assemble the lower ligand loop (a.k.a. nucleotide loop) and form unique C-Co bond present in CoB12 presence or absence of molecular oxygen. During studies assembly Typhimurium, we noticed that growth this bacterium could be...

T-DMB (Terrestrial Digital Multimedia Broadcasting) system, is based on the Eureka-147 standard, provides various multimedia data services. However TDMB needs more various services and higher throughput while maintaining reception. Therefore, this paper proposes advanced T-DMB system using the unequal error protection system, hierarchical multi level modulation and various coding scheme which i...

Despite the extensive study of the biosynthesis of the complex molecule B12 (cobalamin), the mechanism by which the lower ligand 5,6-dimethylbenzimidazole (DMB) is formed has remained something of a mystery. However, recent work has identified and characterized a DMB-synthase (BluB) responsible for the oxygen-dependent, single enzyme conversion of FMN to DMB. In this work, we have identified Bl...

The Transmitter Identification Information (TII) provides unambiguous identification of each transmitter in a Digital Audio Broadcast (DAB) and Digital Multimedia Broadcast (DMB) network. Recent researches showed that some useful services, such as location and automatic emergency alert, can be efficiently implemented with the assistance of TII. However many DAB/DMB receivers do not have the TII...

The spectroscopic and electrochemical properties of a series of four RuII polypyridyl complexes are reported. Compounds of the form [Ru(dmb)x(dea)3-x] (x ) 0-3), where dmb is 4,4′-dimethyl-2,2′-bipyridine and dea is 4,4′-bis(diethylamino)-2,2′-bipyridine, have been prepared and studied using static and time-resolved electronic and vibrational spectroscopies as a prelude to femtosecond spectrosc...

OBJECTIVE To establish the association between genetic polymorphisms of HLA-DMA and HLA-DMB and risk of developing trichloroethylene-induced medicamentosa-like dermatitis (TIMLD). METHODS Sixty-one cases were medically confirmed to have been affected with TIMLD and 60 controls were selected from exposed workers who were free from TIMLD. The TIMLD cases and controls were similar in terms of ag...

Excessive alcohol consumption induces oxidative stress and lipid accumulation in the liver. Mitochondria have long been recognized as the key target for alcoholic liver disease (ALD). Recently, the artificial mitochondria-targeted antioxidant MitoQ has been used to treat ALD effectively in mice. Here, we introduce the natural mitochondria-targeted antioxidant demethyleneberberine (DMB), which h...