OBJECTIVES To investigate the association of the major histocompatability (MHC) class II allele haplotype frequencies with the diagnosis of cranial cruciate ligament (CCL) rupture in two breeds of dog. METHODS DNA samples from populations of Labrador Retrievers and Golden Retrievers with CCL rupture and general populations of the same breeds were characterised for three DLA class II loci (DRB...

We explored the association between HLA-B and HLA-DRB1 polymorphisms reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population Yunnan, China. Methods There were 295 patients 265 healthy control subjects (HCs) enrolled study. Clinical data blood samples collected from patients. The genotypes detected SLE HCs. Results A total 74 on loci determined 288 as well 57 re...

Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1 alleles in 160 antibody positive patients compared 1000 controls. Increased risk was observed for DRB1*10, DRB1*14, DRB1*16 DQB1*05, lower DRB1*04, DRB1*13 DQB1*03. H...

A breed-specific polymyositis is frequently observed in the Hungarian Vizsla. Beneficial clinical response to immunosuppressive therapies has been demonstrated which points to an immune-mediated aetiology. Canine inflammatory myopathies share clinical and histological similarities with the human immune-mediated myopathies. As MHC class II associations have been reported in the human conditions ...

BACKGOUND: The prevalence of rheumatoid arthritis (RA) and its specific autoantibodies varies in different populations. This variability depends on the genetic polymorphism immune response genes among which HLA system plays a major role. AIM: We conducted preliminary study distribution HLA-DRB1 HLA-DQB1 first field level alleles sample 100 Albanian patients with RA. METHODS: In this context, we...

HLA (Human Leukocyte Antigen) gene is located on chromosome 6’s short arm, including several loci. genotyping necessary for transplantation, especially in hematopoietic stem cell transplantation. A cross-sectional study to determine the frequency of HLA-A, HLA-B, and HLA-DRB1 alleles 122 patients admitted National Children’s Hospital Hematopoietic transplantation from year between 2010 2020. Th...

  Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA ...