OBJECTIVE In 2006, the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for Paediatric Endocrinology (ESPE) published a consensus statement on management of intersex disorders. The aim of our study was to determine the etiological distribution of disorders of sex development (DSD) according to the new DSD classification system and to evaluate the clinical features of ...

Malignant germ cell tumor (GCT) formation is a well-known complication in the management of patients with a disorder of sex development (DSD). DSDs are defined as congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. DSD patients in whom the karyotype - at least at the gonadal level - contains (a part of) the Y chromosome are at increased risk for ne...

background: chromosome abnormality (ca) including sex chromosomes abnormality (scas) is one of the most important causes of disordered sexual development and infertility. scas formed by numerical or structural alteration in x and y chromosomes, are the most frequently ca encountered at both prenatal diagnosis and at birth. objective: this study describes cytogenetic findings of cases suspected ...

BACKGROUND Abnormal fetal testis development can result in disorders of sex development (DSDs) and predispose to later testicular dysgenesis syndrome (TDS) disorders such as testicular germ cell tumours. Studies of human fetal testis development are hampered by the lack of appropriate model, and intervention systems. We hypothesized that human fetal testis xenografts can recapitulate normal dev...

Disorders of sex development (DSDs) are congenital anomalies that affect sexual differentiation of genitourinary organs and secondary sex characters. A common cause of female genital virilization is congenital adrenal hyperplasia (CAH), in which excess androgen production during development of 46XX females can result in vaginal atresia, masculinization of the urethra, a single urogenital sinus,...

Like fingerprints, genitalia are unique from person to person, including those who are intersex. Someone with an intersex condition could have external genitalia that are ambiguous or their genitalia might be different from their genetic sex. They could have female genitalia on the outside but be genetically male, they may have both testes and ovaries, or they may have some other combination wh...

Like fingerprints, genitalia are unique from person to person, including those who are intersex. Someone with an intersex condition could have external genitalia that are ambiguous or their genitalia might be different from their genetic sex. They could have female genitalia on the outside but be genetically male, they may have both testes and ovaries, or they may have some other combination wh...

Like fingerprints, genitalia are unique from person to person, including those who are intersex. Someone with an intersex condition could have external genitalia that are ambiguous or their genitalia might be different from their genetic sex. They could have female genitalia on the outside but be genetically male, they may have both testes and ovaries, or they may have some other combination wh...

Like fingerprints, genitalia are unique from person to person, including those who are intersex. Someone with an intersex condition could have external genitalia that are ambiguous or their genitalia might be different from their genetic sex. They could have female genitalia on the outside but be genetically male, they may have both testes and ovaries, or they may have some other combination wh...