The Rockefeller University Press $30.00 J. Cell Biol. Vol. 205 No. 1 97–111 www.jcb.org/cgi/doi/10.1083/jcb.201310035 JCB 97 C.F. Bentzinger and J. von Maltzahn contributed equally to this paper. Correspondence to Michael A. Rudnicki: [email protected] J. von Maltzahn’s present address is Fritz Lipmann Institute for Age Research, 07745 Jena, Germany. Abbreviations used in this paper: Dvl, Dishe...

The beeping of the mobile phone awoke Prof. Hod Lipson in the middle of the night. "We found the equation!" his research student, Michael Schmidt, announced. The equation Schmidt was referring to has been known to every physicist since the 19th century. It describes the Law of Conservation of Energy not exactly an earthshaking discovery. Nevertheless, as Prof. Lipson laid his head of disheveled...

OBJECTIVE To investigate the effect of Astragaloside IV (AS-IV) on the regulation of the Wnt/β-catenin signaling pathway in rats with unilateral ureteral obstruction (UUO). METHODS Rat renal interstitial fibrosis models were prepared using unilateral ureteral ligation. Rats were randomly divided into sham group, sham group with AS-IV (33mg/kg), unilateral ureteral obstruction group, and unila...

Abstract The atmospheric turbulence characteristics in the coastal region of Qatar are analyzed using measurements conducted on shoreline (26.08 N, 51.36 E). micrometeorological data were collected, from August 2015 to September 2016, sonic anemometers (20 Hz) at three heights and a weather station atop 9-m tower. studied within framework Monin–Obukhov similarity theory (MOST), presence inhomog...

BACKGROUND Investigations of naturally-occurring mutations in animal models provide important insights and valuable disease models. Lamins A and C, along with lamin B, are type V intermediate filament proteins which constitute the proteinaceous boundary of the nucleus. LMNA mutations in humans cause a wide range of phenotypes, collectively termed laminopathies. To identify the mutation and inve...

BACKGROUND Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity. It has been shown to promote proper cell polarization during embryonic development in both Xenopus and Drosophila. Importantly, DAAM1 binds to Disheveled (Dvl) and thus functions downstream of the Frizzled receptors. Little is known of ...

“Ms. A,” a 25-year-old woman with paranoid schizophrenia, presented with an acute psychotic episode after having stopped taking her medication. She reported auditory hallucinations and was noted to be disheveled and to have loud, pressured speech, disorganization of thought processes, and persecutory delusions. Over a 10-hour period in the emergency department, she received two intramuscular in...