Whereas cohesin cleavage alone did not produce any detectable effects on engaged centrioles, Cdk inhibition, in contrast, was sufficient to induce centriole disengagement even in the absence of proper chromosome disjunction. Upon p27 injection, centriole disengagement was observed with a similar kinetics to the disengagement observed in the TEV+p27 experiments (Figure 1). Our previous experimen...

OBJECTIVE To determine rates of, and factors associated with, disengagement from care in a decentralised antiretroviral programme. METHODS Adults (≥16 years) who initiated antiretroviral therapy (ART) in the Hlabisa HIV Treatment and Care Programme August 2004-March 2011 were included. Disengagement from care was defined as no clinic visit for 180 days, after adjustment for mortality. Cumulat...

Moral disengagement processes are cognitive self-justification processes of transgressive actions that have been hypothesized to be learned and socialized within social contexts. The current study aimed at investigating socialization of moral disengagement by friends in two developmentally different age groups, namely late childhood (age: 9-10 years; n = 133, 42.9% girls) and early adolescence ...

• We propose an ethical intervention with the potential to reduce unethical decision-making. • We challenge the relationship between moral disengagement and unethical decision-making. • We use attachment theory as the basis for the ethical intervention. • Individuals primed with attachment anxiety experience the usual effects of moral disengagement. • However, individuals primed with attachment...

Children with autism may have difficulties with visual disengagement-that is, inhibiting current fixations and orienting to new stimuli in the periphery. These difficulties may limit these children's ability to flexibly monitor the environment, regulate their internal states, and interact with others. In typical development, visual disengagement is influenced by a phasic alerting network that i...

To address gaps in the literature regarding the role of family routine on school disengagement and delinquent behaviors, we tested whether family routine moderated relations between school disengagement and delinquent behaviors in an urban, low socioeconomic status (SES), African American sample of adolescents (N = 204, 48% male). Adolescents reported on school disengagement and delinquent beha...

When providing social accounts (Sitkin & Bies, 1993) for the unethical conduct of subordinates, leaders may use language consistent with cognitive strategies described by Bandura (1991, 1999) in his work on moral disengagement. That is, leader's social accounts may reframe or reconstrue subordinates' unethical conduct such that it appears less reprehensible. We predict observers will respond ne...

Background The validity of inferences based on (average) test scores obtained from large-scale assessments depends heavily on test-takers’ engagement when taking the test, that is, the degree to which they were motivated to show what they actually know and can do, in other words, to deliver their maximum performance (Cronbach 1970). However, in Abstract Background: A potential problem of low-st...