STUDY OBJECTIVES Sarcoidosis is a granulomatous disorder primarily affecting the lung, but with frequent extrapulmonary organ involvement. There are no comprehensive scoring systems for sarcoidosis disease severity. Our goal was to develop and validate an objective and comprehensive sarcoidosis disease severity scoring system. DESIGN Three sarcoidosis experts reviewed clinical data on 104 pat...

OBJECTIVES Modified adult disease severity scoring systems are being used for childhood FMF. We aim to test the clinical consistency of two common severity scoring systems and to evaluate the correlation of scores with the type of FMF mutations in paediatric FMF patients since certain mutations are prone to severe disease. METHODS Two hundred and fifty-eight children with FMF were cross-secti...

BACKGROUND Parthenium dermatitis is the most common type of airborne contact dermatitis in India. It is a chronic disease of a remitting and relapsing course with significant morbidity and distress, but there is no scoring system to assess its severity. AIM To design a scoring system for the assessment of clinical severity of disease in Parthenium dermatitis and to use this scoring system in ...

context celiac disease (cd) is defined as a permanent intolerance to ingested gluten. the intolerance to gluten results in immune-mediated damage of small intestine mucosa manifested by villous atrophy and crypt hyperplasia. these abnormalities resolve with initiationa gluten-free diet. evidence acquisition pubmed, ovid, and google were searched for full text articles published between 1963 and...

Clinical studies of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) enroll patients with a very wide spectrum of disease, in part, related to the patient and/or host, the causative pathogen, and the severity of the pulmonary disease, severity of illness, and other comorbidities. Studies have identified the presence of some baseline variables (eg, Acute Physiologic As...

background cystic fibrosis is a complex progressive disease which assessing its progression and severity is essential. for this purpose there are scoring systems available to evaluate the disease severity. objectives the aim of the present study was to determine the clinical status of cf patients using shwachman score system in the pediatric pulmonary ward of masih daneshvari hospital. patients...

Introduction: Chronic liver disease and cirrhosis are the most important causes of growth failure, morbidity and mortality in children. Cirrhosis consists of a variety of congenital, genetic, metabolic, and infectious causes in children. Models for predicting of chronic liver disease severity, survival, and transplantation are useful for decision-making as well as medical interventions. The mo...

BACKGROUND Gaucher disease is the first lysosomal storage disease for which specific therapy became available. Over 4800 patients have been treated with enzyme replacement therapy. Analysis of Gaucher disease registry data has outlined the clinical heterogeneity of the disease and the different responses to treatment from patient to patient, and for different organs. This variability in clinica...

INTRODUCTION The burden of rotavirus gastroenteritis is greatest in India and other developing countries. With the availability of two licensed vaccines and a number of additional vaccines in various stages of development and trial, analysis of detailed clinical information is essential for the development of a uniform method of severity assessment. METHODS Diarrhoeal stool samples from 1001 ...