The introduction of one acetyl group into the chymotrypsin molecule by reaction with p-nitrophenyl acetate gives rise to an enzymatically inactive monoacetylated protein that rapidly loses its acetyl group and becomes active again in solutions of dilute alkali or primary alcohols." 2 On the other hand, the well-known polyacetylation of proteins with acetic anhydride, as described by Fraenkel-Co...

SUMMARY Three cases ofauto-immune addison's disease are reported in association with hyperprolactilinemia. All of them had galactorrhea. In three cases complete resolution of hyperprolactitinemia occurred with corticosteroid replacement. We suggest that hyperprolactinemia was due to cortisol deficiency operating directly or indirectly at the level of the pituitary.  

While epidemiological studies have suggested that aluminum is a risk factor for Alzheimer disease (AD), the underlying mechanism through which aluminum leads to AD remains unknown. Despite the lack of evidence linking aluminum to AD that have motivated many to avoid using materials such as cooking utensils made with the metal, researchers have yet to investigate the precise effects of aluminum ...

Adoptive transfer of regulatory T cells (Tregs) prevents GVHD in experimental animals. Because antigen activation drives Treg function, we measured the frequency, growth requirements, and function of alloantigen-specific (allospecific) Tregs from human blood. When alloantigen was presented directly, the precursor frequency of allo-specific Tregs in normal individuals was 1.02% (95% confidence i...