نتایج جستجو برای: direct macrocyclization
تعداد نتایج: 425220 فیلتر نتایج به سال:
Macrocyclization between head, tail or sidechains is a frequently employed strategy to enhance peptide and peptidomimetic stability, selectivity affinity.
An intramolecular Prins macrocyclization reaction was successfully employed in the synthesis of polycavernoside A.
Key words (‒)-exiguolide - macrolide marine natural product macrocyclization ring-closing metathesis transannular cyclization
Two procedures for the synthesis of benzo-21-crown-7 have been explored. The [1+1] macrocyclization with KBF₄ as the template was found to be more efficient than the intramolecular macrocyclization without template. Pseudorotaxanes form with secondary ammonium ions bearing at least one alkyl chain narrow enough to slip into the crown ether. Substitution on benzo-21-crown-7 or on the secondary a...
One-pot, multi-molecular macrocyclization allows the highly selective preparation of strained macrocyclic aromatic hexamers structurally stabilized by an inward-pointing continuous hydrogen-bonding network.
A series of new pentadentate thioether-oximes (TtoxH2, MeTtoxH2, OdtoxH2) were synthesized along with their Ni(II) and Cu(II) complexes. BF2 -bridging is accomplished by reaction of the H-bonded oxime complex with BF3·OEt2, though when Cu(BF4)2 is used as the Cu(II) salt, direct macrocyclization occurs during the metal complexation reaction. Crystallographic studies reveal: [Cu(TtoxH)]ClO4 has ...
in this research work, we report the synthesis of macrocyclic diamides from the reaction of diesters and aliphatic diamines in the presence of caesium carbonate. it has been demonstrated that among the carbonate of alkali metals (li2co3, na2co3, k2co3 and cs2co3), cs2co3 appear to be the best catalyst for macrocyclization. diesters with different substitution patterns on the aromatic ring react...
One-pot, multi-molecular macrocyclization allows the highly selective preparation of pentagon-shaped circular aromatic pentamers mediated by an inward-pointing continuous hydrogen-bonding network.
In this research work, we report the synthesis of macrocyclic diamides from the reaction of diesters and aliphatic diamines in the presence of caesium carbonate. It has been demonstrated that among the carbonate of alkali metals (Li2CO3, Na2CO3, K2CO3 and CS2CO3), CS2CO3 appear to be the best catalyst for macrocyclization. Diesters with different substitution patterns on the aromatic ring react...
Oligomerization and macrocyclization reactions are key steps in the biosynthesis of many bioactive natural products. Important macrocycles include the antibiotic daptomycin (1; ref. 1), the immunosuppressant FK-506 (2; ref. 2), the anthelmintic avermectin B1a (3; ref. 3) and the insecticide spinosyn A (4; ref. 4); important oligomeric macrocycles include the siderophores enterobactin (5; ref. 5...
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