Anticoagulants are the cornerstone of therapy for conditions associated with arterial and venous thrombosis. Direct thrombin inhibitors (DTIs) are anticoagulants that bind to thrombin and block its enzymatic activity. The bivalent parenteral DTIs hirudin and bivalirudin were based on the observation that the salivary extracts of medicinal leeches prevented blood from clotting. Key events that f...

A geothermal direct-use project utilizes a natural resource, a flow of geothermal fluid at elevated temperatures, which is capable of providing heat and/or cooling to buildings, greenhouses, aquaculture ponds, and industrial processes. Geothermal utilization requires matching the varied needs of the user and characteristics of the resource in order to development a successful project. Each appl...

foreign direct investment has been a key topic in development literature for a long time. many economists have written articles on the on recipient’s macroeconomic variables, transfer of capital and technology. the improvement of managerial and human resources, promotion of foreign trade with its emphasized role on economic growth of recipients. other economists have an opposite view. they have...

This study's the question how well moral educators know their students' moral views, is part of the more general question whether they base their efforts to foster moral development on adequate understanding of children. The findings show that most teachers indeed seem to possess a stereotypical image of the student. In order to reduce pluralistic ignorance, I recommend that moral educators sho...

Foreign direct investment has contributed significantly to Chinese economic development. Yet the geographic distribution of FDI is quite uneven. Compared with the inward FDI in the eastern and mid regions of China, the Western region has attracted less FDI. FDI is fuelling much of the rapid economic leap of the developed regions of China and the significant inequity grows further. There are man...

This paper describes the design and implementation of a tool to allow people without programming experience to customize the functionality and user interface of a multi-device museum guide. It consists of a direct-manipulation visual environment that supports editing of the main features of a museum guide and the creation of the associated interactive games. The tool then generates application ...

Through inward perceptions, we intuitively expect distributed software development to increase the risks associated with achieving cost, schedule, and quality goals. To compound this problem, agile software development (ASD) insists one of the main ingredients of its success is cohesive communication attributed to collocation of the development team. The following study identified the degree of...

In this paper we report on ongoing research into the empirical validation of aspect-oriented coupling measures as indicators of maintainability of aspectoriented software. We investigated the aspects of a medium-scale software package developed in industry and measured the maintenance effort that was spent on this software as the number of changed lines throughout the history of each aspect. Th...

Through inward perceptions, we intuitively expect distributed software development to increase the risks associated with achieving quality goals. To compound this problem, agile software development (ASD) maintains that face-to-face (synchronous) communication attributed to co-location of the development team is a key success factor. The following study explored the relationship between synchro...