Bay-region diol epoxides are ultimate carcinogenic metabolites of a number of polycyclic aromatic compounds. Dibenz[a, h]acridine can form two diastereomeric pairs of these diol epoxides which are not positionally equivalent as a result of the nitrogen atom at position 7. We have assessed the structure-activity relationships resulting from heterocyclic nitrogen substitution by examining the mut...

Betaand gamma-eudesmols mixture was microbiologically transformed by Gibberella suabinetti ATCC 20193. Seven different eudesmanoidal metabolites (3Ð9) were isolated and their structures were elucidated by the different spectroscopic techniques. These metabolites are: eudesma-4-en-11-ol-3-one (carissone), eudesma-3-en-2 , 11-diol, eudesma-4-en-3 ,11diol, eudesma-4(15)-en-8,11-diol, eudesma-4(15)...

Ultraviolet and heat-curable polyurethane acrylate prepolymers were synthesized from 4,4’-diphenyl methane diisocyanate, polyethylene adipate diol, polyhexamethylene carbonate diol, polycaprolactone diol and 1,6hexamethylene diamine , acrylic acid. Effects of nature of the soft segments on the physical properties were investigated. It was found that the thermal stability increased from polycarb...

The stereochemistry of diol epoxide formation in mouse epidermis upon topical applicationof [3H]-l/f,2A-dihydroxy-l,2-dihydro-5-methylchrysene (|3H|-5-MeC-l/f,2A-diol)and |3Hl-6-MeC-lÄ,2Ä-diol, and the tumorigenicityin mouse skin and in newborn mice of the R,S,S,R and S,R,K,S enantiomers of l,2-dihydroxy-3,4-epoxy-l,2,3,4-tetrahydro-5methylchrysene (5-MeC-l,2-diol-3,4-epoxide), 5-MeC-7,8-diol...

The present study describes the effect of NCO/OH and triol/diol ratios on the mechanical properties of Nitro functionalized Hydroxyl-terminated polybutadiene (Nitro-HTPB) elastomers. The progress of the cure reaction of Nitro-HTPB and toluene diisocyanate (TDI) is evaluated by following up the variations in the IR absorption bands of the NCO stretching and the CO ...

The metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-diol) by prostaglandin synthetase and cytochrome P-450-dependent monooxygenases was studied using enriched fractions of Clara cells and alveolar type II cells from rat lung. Arachidonic acid-fortified fractions enriched in Clara cells and alveolar type II cells metabolized BP-7,8-diol to the 7,10/8,9-tetrol of benzo(a...

Highly purified cytochromes P-450(LM2) and P-450(LM4) and partially purified P-450(LM1), P-450(LM3b), and P-450(LM7) from rabbit liver microsomes exhibit different catalytic activities in the metabolism of benzo[a]pyrene (BzP) and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene [(-)trans-7,8-diol] in a reconstituted enzyme system. The two highly purified cytochromes also exhibit differences i...

The reactions with DNA and mutagenic activities toward Salmonella typhimurium TA 100 of the R,S,S,R and S,R,R,S enantiomers of antil,2,-dihydroxy-3,4-epoxy-l,2,3,4-tetrahydro-5-methylchrysene (anti5-MeC-l,2-diol-3,4-epoxide), an»i-5-MeC-7,8-diol-9,10-epoxide, and «nf/-6-MeC-l,2-diol-3,4-epoxide were compared because among these compounds only the H,S,S,K enantiomer of anri-5-MeC-l,2-diol-3,4e...

In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The stru...

The fjord-region diol-epoxides of benzo(c)phenanthrene combine high mutagenic and carcinogenic activity with low chemical reactivity. To study whether this is a unique property of these compounds or a more general characteristic of fjord-region diol-epoxides, we have synthesized the anti- and syn-diastereomers of r-9,t-10-dihydroxy-11,12-oxy-9,10,11,12-tetrahydrobenzo(c)chrysene and r-11-t-12-d...