In situ drug and organic electrolyte complex tablets were investigated as extended release dosage forms. Incorporating a 1:1 molar ratio of diltiazem HCl and an anionic organic electrolyte (i.e., Na deoxycholate) into HPC tablets extended the total release time with a near zero – order release rate (release exponent, n = 0.85 – 0.97) due to in situ complex formation of the drug and the organic ...

The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic...

This study presents a rapid, sensitive and accurate high performance liquid chromatographic (HPLC) method for determination of propranolol HCl in human plasma. Human plasma samples were subjected to protein precipitation by methanol and protein free plasma samples were directly injected into HPLC C18 column. Mobile phase consisting of a mixture of acetonitrile: pH 4.5 phosphate buffer (35:65) w...

Objective: The purpose of this study was to determine the optimum formula diltiazem HCl-loaded chitosan nanoparticles due variations in speed and duration stirring evaluating release kinetics vitro using DDSolver.
 Methods: method used prepare is ionic gelation. gelation involves an cross-linking between cations on backbone anion, such as sodium tripolyphosphate (Na TPP). 
 Results: S...

The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects. Utilization of cyclodextrins attracted the attention of many researchers for the enhancement of the dissolution rate. The complexation of diltiazem hydrochloride with βcyclodextrin (CD) was investigated by phase solubility. Phase solubility study was performed to determine stiochio...

Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (...