Considering various biomedical significance & with a view of pharmacological actions compound belong to this class, new series N-(substituted phenyl)-2-methyl-4-(2-(6-oxo-1-phenyl-1-6-dihydro-[2-3-bipyridin]-5-yl)phenyl)-1-4-dihydro pyrimido [1, 2-a] benzimidazole-3-carboxamide ware prepared. The formation the was accomplished by cyclocondensation 2-(1, 2-dihydro-2-oxo-1-phenyl-5-(pyridin-2...

An undescribed phyllocoumarin-3-O-α-L-rhamnopyranoside 8 together with catechin 1, catechin-3-O-α-L-rhamnopyranoside 2, catechin-[7,8-bc]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 3, 5-O-trans-p-coumaroylquinic acid 4, trans-p-coumaric 5, catechin-[5,6-e]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 6, catechin-[5,6-e]-4α-(3,4-dihydroxyphenyl)-dihydro-2(3H)- pyranon 7, phyllocoumarin 9 a...

Reaction of methyl-2-(2-formylphenyl)acetate with primary amines in a reductive amination/cyclisation process resulted N-substituted 1,4-dihydro-3(2H)-isoquinolinones. With H2NCH2R sodium borohyride is suitable reductant (11 examples), but H2NCHR1R2 required transfer hydrogenation using ammonium formate catalysed by palladium on carbon (9 examples). 4-Substituted-1,4-dihydro-3(2H)-isoquinolinon...

The genus Boswellia is one of the 17 genera belonging to Burseraceae family. In this study resin of Boswellia carteri birdwoodcollected or purchased from Tehram herbal Market as a food and non-food for chemical analysis. The essential oils of the resins of Boswellia carteri birdwoodobtained by different methods of distillation (water distillation, steam distillation and hydro-steam distillation...

Abstract Inverse electron-demand Diels–Alder additions (iEDDA) between 1,2,4,5-tetrazines and suitable unsaturated dienophiles such as olefins, alkynes, or enol ethers provide facile access to pyridazines. Herein the use of cyclic ether derivatives for preparing pyridazines bearing 2-hydroxyethyl, 3-hyproxypropyl, 3-oxopropyl substituents at 4-position is disclosed second order rate constants r...

Environmentally friendly synthetic methods were developed for the selective preparation of new 2,3-dihydro-1,4-thiaselenine derivatives in high yields based on reactions 2-bromomethyl-1,3-thiaselenole with alcohols and water at room temperature. The reaction was accompanied by a rearrangement ring extension, leading to six-membered heterocyclic compounds, family 2-organyloxy-2,3-dihydro-1,4-thi...

The biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy- 5,6-dihydro prodrugs to S-ethyl-2'-deoxyuridine (EDU) including (-)-trans-(5S, 6S)-S-bromo-S-ethyl-6-methoxy-S, 6-dihydro-2'-deoxyuridine (BMEDU), (+ )-trans( SR, 6R)-S-bromo-S-ethyl-6-ethoxy-S, 6-deoxyuridine (BEEDU), (+ )-trans-(SR, 6R)-5-bromo-5-ethyl-6-ethoxy -S, 6-dihydro-S '-O-valeryl-2 ':.deoxyuridine (VBE...