Introduction:  In order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (DTC), after L-T4 withdrawal (short-term overt hypothyroidism) and during TSH suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. Methods: 24 patients with DTC were studied in two phases: 1: at least 4 weeks after L-T4 withd...

Thyroid hormone stimulates cardiac inotropy and chronotropy via direct genomic non-genomic mechanisms. Hyperthyroidism magnifies these effects, resulting in an increase heart rate, ejection fraction blood volume. also affects thrombogenesis this may be linked to a probable tendency toward thrombosis patients with hyperthyroidism. Patients hyperthyroidism are therefore at higher risk for atrial ...

introduction:  in order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (dtc), after l-t4 withdrawal (short-term overt hypothyroidism) and during tsh suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. methods: 24 patients with dtc were studied in two phases: 1: at least 4 weeks after l-t4 withdr...

BACKGROUND Metformin is one of the most widely prescribed antidiabetic medications with a favorable safety profile. In the last decade, several studies have reported a TSH-lowering effect of metformin in patients with diabetes mellitus. OBJECTIVE To review literature data on the role of metformin use on thyroid function tests and the course of thyroid cancer. METHODS WE PERFORMED A SEARCH I...

Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic...

Untreated hyperthyroidism and high-dose thyroid hormone are associated with osteoporosis, and increased bone mineral density (BMD) has been demonstrated in postmenopausal females with hypoparathyroidism. Studies on the effect of suppressive levothyroxine (LT4) therapy on BMD and bone metabolism after total thyroidectomy in patients with differentiated thyroid carcinoma have presented conflictin...

We studied a new commercially available thyrotropin (TSH) assay, the AquaLite Bioluminescence TSH-Immunoassay (SeaLite Inc.). This assay has a detection limit of 0.005 mIU/L and a functional sensitivity of 0.017 mIU/L and meets the requirements of a third-generation TSH assay. Using this assay, we measured serum TSH in 153 euthyroid individuals and in the following patients: 32 primary hypothyr...

Levothyroxine (L-T) is one of the most commonly prescribed medications. It is given as either physiologic replacement therapy in patients with hypothyroidism or as interventional therapy to suppress thyroid-stimulating hormone (TSH) secretion in patients with nodular thyroid disease or thyroid cancer. Patients treated with L-T4 suppressive therapy (a state known as exogenous subclinical hyperth...

Differentiated thyroid cancer is the most common endocrine malignancy and the incidence is increasing rapidly worldwide. Appropriate diagnosis and post-treatment monitoring of patients with thyroid tumours are critical. Fine needle aspiration cytology remains the gold standard for diagnosing thyroid cancer, and although there have been significant refinements to this technique, diagnostic surge...

BACKGROUND/OBJECTIVES Thyroid hormone receptors are present on brown adipose tissue (BAT), indicating a role for thyroid hormone in the regulation of BAT activation. The objective of this study was to examine the effect of thyroid hormone withdrawal followed by thyroid hormone in TSH-suppressive dosages, on energy expenditure and brown adipose tissue activity. SUBJECTS/METHODS This study was ...