Tumorigenesis requires the re-organization of metabolism to support malignant proliferation. We examine how the altered metabolism of cancer cells is reflected in the rewiring of co-expression patterns among metabolic genes. Focusing on breast and clear-cell kidney tumors, we report the existence of key metabolic genes which act as hubs of differential co-expression, showing significantly diffe...

Recent studies have implicated the role of differential co-expression or correlation structure in gene expression data to help explain phenotypic differences. However, few attempts have been made to characterize the function of variants based on their role in regulating differential co-expression. Here, we describe a statistical methodology that identifies pairs of transcripts that display diff...

Differential co-expression network analyses have recently become an important step in the investigation of cellular differentiation and dysfunctional gene-regulation in cell and tissue disease-states. The resulting networks have been analyzed to identify and understand pathways associated with disorders, or to infer molecular interactions. However, existing methods for differential co-expressio...

BACKGROUND The analysis of co-localized protein expression in a tissue section is often conducted with immunofluorescence histochemical staining which is typically visualized in localized regions. On the other hand, chromogenic immunohistochemical staining, in general, is not suitable for the detection of protein co-localization. Here, we developed a new protocol, based on chromogenic immunohis...

The present work describes a selective, rapid and sensitive method for the determination of cobalt using the adsorptive differential pulse voltammetry technique. The method is based on the accumulation of Co(II) complex with 2-aminocyclopentene-1-dithiocarboxylic acid on a hanging mercury drop electrode, followed by measurement of the current of the adsorbed complex. The effects of experimental...

Differential scanning calorimetry (DSC), temperature programmed desorption mass spectrometry (TPD-MS) and small angle neutron scattering (SANS) were used to investigate CO2 uptake by the Wyodak coal. Adsorption of carbon dioxide on Wyodak coal was studied by DSC. The exotherms evident at low temperatures are associated with the uptake of CO2 suggesting that carbon diox...

Comparing the gene-expression profiles of sick and healthy individuals can help in understanding disease. Such differential expression analysis is a well-established way to find gene sets whose expression is altered in the disease. Recent approaches to gene-expression analysis go a step further and seek differential co-expression patterns, wherein the level of co-expression of a set of genes di...

background although neuregulin-1 （nrg1）and its receptors have been indicated at the mrna level in partial human endocrine organs and its functional roles have been evaluated in vitro, their morphological distribution in higher animals are not fully studied. the present research focused on expression of nrg1 and its main receptors erbb2 and erbb4 in main endocrine organs of the rhesus monkey. ma...

In the present review we provide an extensive analysis of intertwinement between Feynman integrals and cohomology theories in light recent developments. enter several perturbative methods for solving non-linear PDE, starting from Quantum Field Theories including General Relativity Condensed Matter Physics. Precision calculations involve loop onec strategy to address, which is bring them back te...