a relatively constant amount of dieldrin, a chlorinated hydrocarbon insecticide, is directly related to obesity. This relationship should be applicable regardless of the route of absorption of dieldrin (ingestion, inhalation, or percutaneous). Forced feeding of a high calorific value food appears to have a place in the treatment of dieldrin poisoning and, by extension, in the treatment of poiso...

Dieldrin is a technical product containing 85% of H.E.O.D., the approved name for 1,2,3,4,10,10,hexachloro-exo-6,7-epoxy1,4,4a ,5,6,7,8,8a-octahydro-exo -1,4, endo -5,8,dimethanonaphthalene. The remaining 15% of the technical product consists of active isomeric compounds. Dieldrin is a powerful insecticide that has been extensively used in agriculture, food storage, and public health work. Wher...

Dieldrin was previously used as a pesticide. Although its use has been discontinued, humans are still exposed to it due to its high environmental persistence and because it accumulates in the adipose tissue of animals. Acute exposure to dieldrin provokes convulsions due to its antagonism on the gamma-aminobutyric acid-A (GABA(A)) receptor. However, little is known about the effects of low chron...

Dieldrin is an endocrine disruptor that accumulates in mammalian adipose tissue and brain. It induces convulsions due to its antagonism of the γ-aminobutyric acid A receptor (GABA(A)R). We have previously reported that long-term exposure to dieldrin causes the internalization of the N-methyl-D-aspartate receptor (NMDAR) as a result of persistent GABA(A)R inhibition. Because the neurosteroids 17...

The effects of naturally occurring microsomal enzyme inducers on hepatocellular drug-metabolizing enzyme systems and also upon the incidence of "spontaneous" liver tumors in CF-1 mice were investigated, using animals maintained on semisynthetic diet and filter-paper bedding as controls. The administration of dieldrin, a potent microsomal enzyme inducer with tumorigenic properties in livers of C...

The capability of bait lamina to assess biological activity of soil fauna in semi-arid zone was studied in a peri-urban area polluted by dieldrin. This method was compared to litter bags usually used in this savannah region to monitor the activity of soil macro-invertebrates. The study site is used for agriculture and the irrigation water contains known concentrations of dieldrin residues. Thre...

Fipronil and dieldrin are known to inhibit GABA receptors in both mammals and insects. However, the mechanism of selective toxicity of these insecticides between mammals and insects remains to be seen. One possible mechanism is that insect GABA receptors are more sensitive than mammalian GABAA receptors to fipronil and dieldrin. We examined differential actions of fipronil and dieldrin on GABA-...

BACKGROUND We previously screened 400 elderly Costa Ricans for neurodegenerative disease. Those reporting occupational pesticide exposure (18%) had an increased Parkinson׳s disease (PD) risk (OR 2.57, 95% CI 0.91-7.26), and worse cognition (Mini-Mental States Exam (MMSE) 24.5 versus 25.9 points, p=0.01). We subsequently measured long-lasting organochlorine pesticides (β-HCH, DDE, DDT, and dield...

The kinetics of nuclear polyploidization in livers of CF-1 mice exposed to dieldrin were studied at concentrations of 0, 0.1, 1, 5 and 10 p.p.m. in the diet, in 'steady-state' situations (which are reached within a few weeks after initiation of treatment). Animals were killed at five time intervals (after 1.85, 3, 6, 9 and 14 months of exposure). The changes in the percentage of octaploid nucle...

The organochlorine chemicals endosulfan, dieldrin, and γ-hexachlorocyclohexane (lindane) are persistent pesticides to which people are exposed mainly via diet. Their antagonism of the γ-aminobutyric acid-A (GABA(A)) receptor makes them convulsants. They are also endocrine disruptors because of their interaction with the estrogen receptor (ER). Here, we study the effects of dieldrin, endosulfan,...