Two novel potentiometric membrane sensors responsive to the ibuprofen drug have been developed. These incorporate poly(vinyl chloride) and polyurethane matrix membranes containing 5,10,15,20-tetraphenylporphrinato (TPP) indium(II) ionophore plasticized with dibutylsebacate. The sensors show a near-Nernstian response with anionic slopes of -53 and -55 mV decade(-1), over the concentration range ...

Experimental determinations of the dynamics of photoinduced electron transfer from rubrene to duroquinone in three solvents, dibutyl phthalate, diethyl sebacate, and cyclohexanone are presented. Measurements of the donor (rubrene) fluorescence decays were made with time-correlated single-photon counting. The data are analyzed using recent theoretical developments that include important features...

Diethyl sebacate is used in topical medicaments in United States and Japan. We described a case of allergic contact dermatitis from diethyl sebacate in a topical antimycotic medicament. Allergic reaction to diethyl sebacate is likely more common because our group has found three of eight sensitized cases. We believe that an investigation regarding the sensitized frequency to diethyl sebacate wo...

Phthalates are a group of multifunctional chemicals used in consumer and personal care products, plastics, and medical devices. Laboratory studies show that some phthalates are reproductive and developmental toxicants. Recently, human studies have shown measurable levels of several phthalates in most of the U.S. general population. Despite their widespread use and the consistent toxicologic dat...

DB is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (Mw), polydispersity index (Mw/Mn) and glass transition temperature (Tg). Neat plasticized films of DB (Damar Batu) are investigated for mechanical, water vapor transmission and moisture absorption properties. To improve the mechanical properties of the free films dibutyl sebacate, a...

Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer improved patient compliance. This study represents the first phase of an investigation into the us...

in this study, damar batu (db) − a novel biomaterial− is evaluated for its potential application in pharmaceutical coating. db is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (mw), polydispersity index (mw/mn) and glass transition temperature (tg). neat plasticized films of db are investigated for mechanical, water vapor transmission...

The estrogenic activity of phthalate esters for dental use as plasticizers was concerned. To study the feasibility of candidate chemicals for phthalate tissue conditioners, three candidate plasticizers, di-n-butyl sebacate, acetyl tributyl citrate and tri-n-butyl phosphate together with conventional plasticizers were examined for estrogenic activity and cytotoxicity using three estrogenicity as...

A GC/MS method was developed for simultaneous determination of 12 phthalates and four other plasticizers--acetyl tributyl citrate, di(2-ethylhexyl) adipate, dibutyl sebacate, di-isononyl cyclohexane 1,2-dicarboxylate (DINCH)--in vegetable oil, pesto, and tomato sauce. Samples were extracted with acetonitrile and cleaned on a Florisil column. The final extract was analyzed by GC in combination w...

Poly(vinyl chloride) membrane sensors for Ca(II) ions were constructed based on bilirubin (1,3,6,7-tetramethyl-4,5-dicarboxyethy-2,8-divinyl-[b-13]-dihydrobilenone) as a neutral carrier in the presence of various plasticizers (o-nitrophenyloctyl ether, dioctyl phethalate and dibutyl sebacate), which were used as solvent mediators to incorporate the carrier into the membranes. The role of plasti...