The solid–solid reactions of electron-donor compounds, such as: barbituric acid (1a), thiobarbituric acid (1b), 1,3-dimethyl barbituric acid (1c), phenol (1d) and resorcinol (1e) with diazotized o-nitroaniline (3), m-nitroaniline (4) and p-nitroaniline (5) catalyzed by p-toluenesulfonic acid (2) afford azo dyes by grinding in good yields. This new method totally avoids the use of inorganic acid...

The Hunter (1) procedure was originally developed for the calorimetric d&&ion of minute amounts of thymine. In this procedure thymine is coupled under air with p-diazobenzenesulfonic acid in carbonate solut.ion, and a red color is subsequently produced by the addition of sodium hydroxide and hydroxylamine. Thymine was determined by this means in hydrolysates of dcsoxypentose nucleic acids (DNA)...

Palladium catalyzed cross-coupling reaction has been developed into one of the most powerful methods for the formation of C-C bonds.1 Recently, remarkable progress has been made in the Pdcatalyzed cross-coupling reactions with carbon nucleophiles derived from active methylene compounds,1d ketones,2 esters,3 amides,4 and nitriles.5 Hydrazones have also been applied in this type of reactions as a...

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

An enzyme immunoassay (EIA) has been developed for determination of 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl) benzimidazole (KB-6806), a novel 5-HT3 receptor antagonist. Anti-KB-6806 antiserum was elicited against the KB-6806-bovine serum albumin (BSA) conjugate prepared by a diazo coupling reaction through the inherent 6-amino group. Beta-galactosidase-labeled 6-amino-5-chloro-1-...

A synthetic approach to the tunicamycins, a complex family of nucleosides with potent antibiotic and antiviral activities is reported based on diazo chemistry. The corresponding precursors for the synthesis of tunicaminyl uracil derivatives, the non-stabilized diazo derived from 13 and the aldehyde derivative of uridine, compound 4, were prepared efficiently from commercially available D-galact...

A series of monoazo disperse dyes based on naphthalimide was synthesized using N-alkylcarboxylic acid-1,8-naphthalimide as diazo component and N,N-diethylaniline derivatives as a coupling components. 4-amino-N-ethanoic (propanoic) acid-1,8-naphthalimide was synthesized from 4-nitro-1,8-naphthalic anhydride by imidation and subsequent reduction reactions. These compounds were diazotized and furt...

Decomposition of donor-acceptor diazo compounds leads to the formation reactive carbene intermediates. These can undergo a wide variety transfer reactions yield synthetically useful products. Herein, we report selective borane catalyzed cyclization reaction from combination two different afford N-substituted pyrazoles. The decomposition more α-aryl α-diazoester and subsequent with vinyl diazoac...