Diazinon (O,O-diethyl-O-[2-isopropyl-6-methyl-4-pyrimidinyl] phosphoro thioate), an organo-phosphate insecticide, has been used worldwide in agriculture and domestic for several years, which has led to a variety of negative effects in non target species including humans. However, its nephrotoxic effects and mechanism of action has not been fully elucidated so far. Therefore, the present study w...

The efficacy of metoclopramide for preventing organophosphate insecticide-induced (diazinon) toxicosis was evaluated in 7~14 days old chicks. Injection of metoclopramide at 25 mg/kg, s.c. 15 min before diazinon increased the oral 24 h median lethal dose of the insecticide in the chicks by 80%. Metoclopramide alone inhibited the in vitro and in vivo plasma and whole brain cholinesterase activiti...

Repeated application of diazinon granules to the soil Surface of rice fields affected the development of a biological factor that caused rapid degradation of diazinon. This factor was present in the paddy water, in rhizosphere soil of the rice plant, and in nonrhizosphere soils. Isotope studies showed that when incubated with water from diazinon-treated fields, diazinon was hydrolyzed to 2-isop...

Amongst organophosphate pesticides, the one most widely used and common environmental contaminant is diazinon; thus methods for its trace analysis in environmental samples must be developed. Use of diazinon imprinted polymers such as sorbents in solid phase extraction, is a prominent and novel application area of molecular imprinted polymers. For diazinon extraction, high performance liquid chr...

It is known that the enzyme activities of non-target organisms are influenced in vivo or vitro by pesticides play a major role to obtain higher yields field agriculture. foreseen used for various purposes may negatively affect lipase, an digestive system, non target organisms. Therefore, this study, effect diazinon (organophosphate class) and carbaryl (carbamate pesticides, which be widely agri...

BACKGROUND There is growing recognition of the significance of the gut microbiome to human health, and the association between a perturbed gut microbiome with human diseases has been established. Previous studies also show the role of environmental toxicants in perturbing the gut microbiome and its metabolic functions. The wide agricultural use of diazinon, an organophosphate insecticide, has r...

Diazinon, an organophosphate pesticide, becomes biotransformed to a more potent oxon metabolite that inhibits acetylcholinesterase (AChE). Early life stages (els) of medaka, Oryzias latipes, were used to determine how development of this teleost affects sensitivity to diazinon. With developmental progression, from day of fertilization to 7-day-old larvae, we found that the 96-h LC50 and AChE IC...

Many feed and forages are exposed to low, medium or high levels of organophosphorous (OP) pesticides. It is unclear whether these exposures (for example diazinon as an OP pesticide) impact dry matter degradability parameters. So, different levels (0, 0.7, 2.8 and 5.6 mg) of diazinon as an OP pesticide with different levels of calcium bentonite (CB) (0 and 100 mg) as a toxin binder were tested f...

The toxicity of mixtures of copper, zinc, and diazinon were determined for Ceriodaphnia dubia using 7-d survival and reproduction tests. Fifteen treatments, including combinations of the chemicals at 0, 25, 50, 75, and 100% of their individual median lethal concentrations, adding up to one toxic unit (TU) were tested. The TU was then used to classify each mixture response as additive, greater t...

Contaminant exposure in aqueous systems typically involves complex chemical mixtures. Given the large number of compounds present in the environment, it is critical to identify hazardous chemical interactions rapidly. The present study utilized a prototype for a novel high-throughput assay to quantify behavioral changes over time to identify chemical interactions that affect toxicity. The indep...