We recently reported that mitochondrial dysfunction, characterized by increased mitochondrial permeability transition (MPT), was present in a translational swine model of heart failure with preserved ejection fraction (HFpEF). Cyclophilin D is a key component of the MPT pore, therefore, the purpose of this study was to test the efficacy of a novel cyclosporine (CsA) dosing scheme as a therapeut...

conclusions in this study there is no correlation between the main lv diastolic indices derived by spect and echocardiography, may be due to the main changes in the last version of guidline for assessment of lv diastolic function by echocardiography. results the population study consisted of 19 male and 30 female with the average age of 58.2 years.there is a mild negative correlation between pf...

Background Cardiac involvement in patients with sarcoidosis is an independent predictor of mortality and associated with very poor prognosis. Inflammatory processes within the myocardium as well as subsequent fibrotic myocardial alterations may lead to diastolic dysfunction and at worst sudden death resulting from ventricular tachy-arrhythmias or conduction block. Diastolic dysfunction as a sig...

BACKGROUND We sought to investigate the association between blood pressure levels and prevalence of acquired color vision impairment in middle-aged Japanese men. METHODS Participants underwent color vision testing, ophthalmological examination, standardized interview, physical record examination, and venous blood examination. Cardiovascular disease risk factors were determined based on blood ...

We tested the hypothesis that glycolytic inhibition by 2-deoxyglucose causes greater impairment of diastolic relaxation and intracellular calcium handling in well-oxygenated hypertrophied adult rat myocytes compared with control myocytes. We simultaneously measured cell motion and intracellular free calcium concentration ([Ca2+]i) with indo-1 in isolated paced myocytes from aortic-banded rats a...

conclusions chronic smoking caused left ventricular diastolic dysfunction. acute intake caused left and right ventricular diastolic dysfunction. changes persisted up to 30 minutes after smoking, although diastolic blood pressure returned to normal state. objectives the current study aimed to evaluate the acute and chronic effects of smoking on the left and right ventricular (rv) diastolic funct...

AIMS The purpose of this study was to test the hypothesis that left ventricular (LV) mechanical dyssynchrony deteriorates the longitudinal systolic and diastolic function of the left ventricle (LV) in patients with heart failure with a normal LV ejection fraction (HFNEF). METHODS AND RESULTS In patients with HFNEF and in a control group consisting of asymptomatic patients with LV diastolic dy...