Dialysis-related amyloidosis (DRA) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. Matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. In clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (H.M.H. and L.M.H.) have been routinely use...

BACKGROUND AND OBJECTIVES Light chain (AL) and secondary (AA) amyloidosis usually present as a systemic disease frequently involving the kidney and leading to ESRD. Data regarding patients with AA or AL amyloidosis undergoing dialysis remain scarce. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We retrospectively studied patients with AA or AL amyloidosis who started dialysis in five French c...

BACKGROUND AND AIMS The liver is frequently involved in amyloidosis but the significance of hepatic amyloid has not been systematically studied. We have previously developed scintigraphy with 123I serum amyloid P component (123I-SAP) to identify and monitor amyloid deposits quantitatively in vivo and we report here our findings in hepatic amyloidosis. METHODS Between 1988 and 1995, 805 patien...

BACKGROUND There are few reports regarding the long-term renal replacement therapy (RRT) outcomes of amyloidosis. METHODS In this retrospective, multi-centre, multi-country registry analysis, all patients with and without amyloidosis who commenced RRT for end-stage renal failure (ESRF) in Australia and New Zealand between 1963 and 2010 were included. RESULTS Of 58 422 patients who underwent...

In March 1999, a 49-year-old woman presented with acute right hip pain and no history of trauma. She had been diagnosed with rapidly progressive glomerulonephritis in 1966 leading to complete renal failure in 1973. Treatment included multiple failed attempts at transplantation and long-term hemodialysis. She was diagnosed with beta-2 microglobulin amyloidosis in 1986. She had a parathyroidectom...

The amyloidoses are a group of protein-misfolding disorders characterized by the accumulation of amyloid fibrils formed from a variety of proteins. Currently, twentyeight different kinds of human and animal proteins, in intact or fragmented forms, have been found to be associated with pathological disorders such as Alzheimer’s disease, type II diabetes, prion diseases, dialysis-related amyloido...

A 69-year-old man presented with a few years’ history of nodules on the buttocks. Past history included chronic renal failure controlled with haemodialysis for 19 years and a decompression operation for carpal tunnel syndrome. Physical examination revealed a red-brown pediculated nodule 50×20 mm in diameter on the sacral region (Fig. 1A). In addition, 120×80 mm elastic, hard subcutaneous masses...