abstract  introduction: diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. this study was designed to investigate the effect of nigella sativum (ns) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (stz)-induced diabetic rats.  methods: for this p...

introduction: one of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. aspirin (asa) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. the aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...

abstract objective: the previous studies indicated that the tlrs especially toll-like receptor 4) tlr4 (are involved in the process of diabetes. the aim of the present research was to investigate the time course expression pattern of tlr4-a main component of innate immune system- in mrna levels in the heart tissue of diabetic male wistar rats. materials and methods: in this research, adult wist...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

introduction: impaired wound healing in diabetic patients is a major clinical problem, which is associated with significant morbidity and mortality. estrogen has positive effects on neoangiogenesis, reepithelialization and cell proliferation. in this research, effect of estrogen on wound healing in diabetic male rats was investigated. methods: this study was performed on male wistar rats (body ...

background the aim of the present study was to investigate the effect of ginger and glibenclamide on oxidative stress markers. oxidative stress is caused by an unbalance between a relative overload of oxidants and depletion of antioxidants, as implicated in the pathogenesis of several chronic diseases, including atherosclerosis and diabetes mellitus. regarding the role of oxidative stress in th...

background: to assess the effect of supplementation with vitamins a, e and c and ω-3 fatty acids on lipid peroxidation in strepto zotocin (stz) induced diabetic rats. methods: sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia betic with vitamin a, e as well as c supplementation and diabetic with ω-3 fatty acids supplementation. aft...

conclusions hexagonal water has no significant effect(s) on total cholesterol, hdl, and ldl; however, more experiments are needed to clarify all aspects of hexagonal water consumption on diabetes. background diabetes is one of the most prevalent abnormalities in all over the world. nowadays, there are lots of attempts to reduce its disturbances and defects by changing life style to access some ...

the aqueous extract of syzygium cumini (pulp) was investigated for its possible hypoglycemic and antioxidant potentials in streptozotocin (stz) induced diabetic wistar female rats. a single intraperitoneal injection of stz at a dose of 55 mg/kg body weight elevated the glucose levels more than 230 mg/dl after 3 days. treatment with the aqueous extract of syzygium cumini (pulp) at 100 mg/kg and ...

objectives: this study investigates the effects of hydro-alcoholic extract of prangos ferulacea (l.) lindle (p.f) on rats' pancreas structure changes and diabetic treatment after streptozotocin injection. materials and methods: in this research forty male wistar rats with body weights of 100±20 gram, were randomly divided into 5 groups with 8 rats per each group. diabetes was induced in ra...