Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons. A numbers of animal models of diabetic...

abstract  introduction: diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. this study was designed to investigate the effect of nigella sativum (ns) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (stz)-induced diabetic rats.  methods: for this p...

We investigated the effect of diabetic plasma on insulin-stimulated DNA synthesis in primary cultured aortic smooth muscle cells (SMC) of the GK rat, a model of non-insulin-dependent diabetes mellitus, and compared it with that of Wistar normal rat plasma. We measured the incorporation of 3H-thymidine into cultured SMC. The diabetic plasma (3%) of GK rat, but neither the plasma (3%) of Wistar n...

The goal of this study was to examine whether alteration of sarcoplasmic reticulum (SR) protein levels is associated with early-onset diastolic and late-onset systolic dysfunction in streptozotocin (STZ)-induced diabetic rat hearts. Four-week diabetic rat hearts exhibited slow relaxation, whereas 6-wk diabetic rat hearts exhibited slow and depressed contraction. Total phospholamban level was in...

Pomegranate fruit peel is an inedible part obtained during the processing of pomegranate juice. Compared to pulp fraction, it contains more total polyphenols and has a better antioxidant potential. Even though they are good sources protein, dietary fiber, variety minerals, phytochemicals, soybeans often have nutritional function. When utilized partially replace wheat in bread items, quality wil...

Hyperglucosylated and normal human and rat albumin were injected intravenously into control and streptozotocin-induced diabetic rats. Binding of injected human albumin to renal basement membranes was not observed by immunofluorescence microscopy in the diabetic or control rats irrespective of the form of injected albumin. However, human albumin was found as tubular droplets in both the control ...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

Serum lipid and lipoprotein composition in spontaneously diabetic BB Wistar rats, nondiabetic littermates, and control Wistar rats was studied to elucidate diabetes-related abnormalities of lipoprotein composition. Serum total triglycerides and pre-beta-lipoprotein concentrations of insulin-treated spontaneously diabetic BB and nondiabetic littermate rats were significantly higher than those of...

objective: diabetes is an important risk factor for cardiovascular events. the great percent of morbidity in patients with diabetes is due to endothelial dysfunction. the present study investigated the effects of hydroalcholic extract of nigella sativa (n. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (stz)-induced diabetic rat. materials and methods: rats ...

Abnormal vascular responsiveness in diabetes has been attributed to a number of changes in contractile pathways, affected in part by the overproduction of reactive oxygen species (ROS). It has been reported that NADPH oxidase (NOX) is increased in diabetic (streptozotocin treated; STZ) rat arteries; however the pharmacological agents used to inhibit NOX activity are known to be unsuitable for i...