Analysis of plasma norepinephrine (NE) concentrations in umbilical artery and vein from infants of diabetic and nondiabetic mothers revealed high plasma NE values in those of diabetic mothers. While birth weight and arterial plasma NE did not correlate in infants of nondiabetic mothers (r = 0.07, NS), birth weight and plasma NE were related inversely in infants of diabetic mothers (r = -0.73, ...

OBJECTIVE To determine the concentration of plasma leptin and other metabolic hormones in offspring of diabetic and none diabetic mothers after 2 weeks of age. The relationship between leptin and metabolic hormones was also investigated. METHODS Included in the study were 79 newborns from the Neonatal Unit at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia from January 20...

INTRODUCTION The aim of the paper is to examine the incidence and the rate of cardio respiratory disorders in mothers of newborns with diabetes mellitus in pregnancy as well as their influence on the perinatal outcome. MATERIAL AND METHODS A prospective and random study included 102 newborns, 31 newborns of mothers with glucose homeostasis disorder (group I) and 71 newborns of healthy mothers...

OBJECTIVE The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 25-hydroxyvitamin D (25OHD) concentration during pregnancy in mothers whose children lat...

BACKGROUND The adverse effects on offspring of diabetic and/or obese mothers can be passed to the next generation. However, the mechanisms behind this are still unclear. Epigenetics may play a key role during this process. METHODS To confirm the hypothesis, we investigated the DNA methylation of several imprinted genes in spermatozoa of offspring from diabetic and/or obese mothers utilizing s...

BACKGROUND Cardiomyopathy is noted in up to 40% of infants of diabetic mothers, and the exact mechanisms responsible for it are unknown. The aim of this study was to compare between infants of diabetic mothers (IDM) and infants of non- diabetic mothers (INDM) as regards cardiac troponin I (cTnI) levels (as a marker of cardiac dysfunction) and to examine the relationship between this marker and ...

BACKGROUND Sucrose is widely used to manage procedural pain in term newborns despite a lack of evidence of its effectiveness for different procedures and infant populations. Our objectives were to evaluate the effectiveness and safety of sucrose in newborns undergoing various medical procedures within 2 days of birth. METHODS We performed a double-blind, randomized controlled trial. We includ...

Materials and methods There were 4 groups (G): G1 (non-pregnant controls rats), females that received intraperitoneal injection (ipi) of 0.9% saline (s), G2 (non-pregnant diabetic rats), females that received ipi of alloxan (100 mg/kg) diluted in 0.9% s, G3 (control mothers), mothers that received ipi of 0.9% s and G4 (diabetic mothers), mothers that received ipi of alloxan (100 mg/kg) diluted ...

BACKGROUND Small for gestational age (SGA) infants are at increased risk of morbidity and mortality. We sought to identify risk factors associated with SGA and examined the potential for reducing the proportion of infants with SGA at a population level. METHODS Birth and hospital records were linked for births occurring in 2007-2010 in New South Wales, Australia. The analysis was stratified i...