one of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. in this study the effect of the male hormone 5a-dht on cytokine release by peritoneal macrophages (mφ) of male and female nzb/balbc mice was investigated. macrophages from male mice activated with lps produced a greater amount of il-1β (21.8%) (p<0.05) and il-6 (19...

BACKGROUND To determine: in vitro binding affinity of equol for 5alpha-dihydrotestosterone (5alpha-DHT), in vitro effects of equol treatment in human prostate cancer (LNCap) cells, and in vivo effects of equol on rat prostate weight and circulating levels of sex steroid hormones. METHODS First, in vitro equol binding affinity for 5alpha-DHT was determined using 14C5alpha-DHT combined with col...

Heat and drought stresses have negative impacts on wheat yield growth worldwide, causing up to 60% 40% losses, respectively, but their combined effect can cause severe losses. The present study aimed identify the high-yielding genetic resources tolerant and/or heat under climate change scenarios. field trials 42 genotypes were conducted at three locations in four environments (normal TSIR-NS, T...

Granulosa cell mitogenesis is critical for the development of normal ovarian follicles. FSH and other mitogenic stimuli play a crucial role in this process. We have shown that exposing granulosa cells to 5alpha-dihydrotestosterone (DHT) reduces forskolin-stimulated cyclin D2 mRNA expression, which leads to cell cycle arrest resulting in reduced cell proliferation. The present study investigated...

Distributed Hash Table (DHT) plays an important role in distributed systems and applications, especially in large-scale distributed environments. In normal Client/Server model (C/S model) since most of the resources is centralized at server, it becomes the most important part as well as the bottleneck and weak point of the system. On the contrary, distributed model (a typical one is peer-to-pee...

Power domain non-orthogonal multiple access combined with a universal filtered multi-carrier (NOMA-UFMC) has the potential to cope fifth generation (5G) unprecedented challenges. NOMA employs power-domain multiplexing support several users, whereas UFMC is robust timing and frequency misalignments. Unfortunately, NOMA-UFMC waveform high peak-to-average power (PAPR) issue that creates negative a...

This study was designed to investigate the effects of exogenous androgen and resistance exercise on skeletal muscle hypertrophy and the role of the mammalian target of rapamycin (mTOR) signalling during the process. A total of 24 male Sprague-Dawley rats were randomly assigned to sham operation and dihydrotestosterone (DHT) implantation groups with subgroups subjected to sedentary conditions or...

We previously reported the selective loss of AKR1C2 and AKR1C1 in prostate cancers compared with their expression in paired benign tissues. We now report that dihydrotestosterone (DHT) levels are significantly greater in prostate cancer tumors compared with their paired benign tissues. Decreased catabolism seems to account for the increased DHT levels as expression of AKR1C2 and SRD5A2 was redu...

Modern arc processes, such as the modified spray (Mod. SA), have been developed for gas metal welding of high-strength structural steels with which even narrow weld seams can be welded. High-strength joints are subjected to increasingly stringent requirements in terms processing and resulting component performance. In present work, this challenge is met by clarifying influences on hydrogen-assi...

The purpose of this study was to investigate the application of salmon atelocollagen (SAC) to a scaffold. SAC has a low denaturation temperature and needs to be cross-linked before being used as a scaffold. In the present study, SAC was cross-linked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) or dehydrothermal treatment (DHT). The material properties (degree of cross-l...