Defibrotide (DF) has received European Medicines Agency authorization to treat sinusoidal obstruction syndrome, an early complication after hematopoietic cell transplantation. DF has a recognized role as an endothelial protective agent, although its precise mechanism of action remains to be elucidated. The aim of the present study was to investigate the interaction of DF with endothelial cells ...

The role of the duty factor (DF) in ultrasound-mediated cardiac stimulation is studied. Five 3-month-old female rats were exposed transthoracically to 3.5-MHz ultrasonic pulses of 2.0-MPa peak rarefactional pressure amplitude, variable DF, and variable pulse repetition frequency. A change in the heart rate was not observed following the 0.25%-DF sequence. A decrease of ∼4% in the heart rate was...

We examined the spatial distribution pattern and meteorological drivers of dengue fever (DF) in Guangdong Province, China. Annual incidence of DF was calculated for each county between 2005 and 2011 and the geographical distribution pattern of DF was examined using Moran's I statistic and excess risk maps. A time-stratified case-crossover study was used to investigate the short-term relationshi...

Although the metabolism and disposition of diclofenac (DF) has been studied extensively, information regarding the plasma levels of its acyl-β-d-glucuronide (DF-AG), a major metabolite, in human subjects is limited. Therefore, DF-AG concentrations were determined in plasma (acidified blood derived) of six healthy volunteers following a single oral DF dose (50 mg). Levels of DF-AG in plasma were...

N 27 27 – Age [years; months] (age range) 10;5±2;7 (6;6–16;4) 11;0±1;11 (8;5–17;0) T=0.81; df=52; P=.42 Sex (f/m) 8/19 7/20 χ=0.09; df=1; P=.76 IQ 80±17 107±12 T=6.55; df=52; Pb .01 CBCL (total t-score) 64.08±9.05 (n=25) 48.67±5.38 T=−7.54; df=50; Pb .01 General ADHD symptoms 1.00±0.51 (n=24) 0.30±0.23 (n=26) T=−6.37; df=48; Pb .01 Depressive symptoms 48.96±9.95 (n=26) 42.89±8.00 T=−2.45; df=51...

BACKGROUND Dengue fever (DF) outbreaks often arise from imported DF cases in Cairns, Australia. Few studies have incorporated imported DF cases in the estimation of the relationship between weather variability and incidence of autochthonous DF. The study aimed to examine the impact of weather variability on autochthonous DF infection after accounting for imported DF cases and then to explore th...

The increase in use and misuse of psychoactive substances is a global challenge of grave public health concern. This study aims to ascertain the patterns and socio-demographic correlates of psychoactive substances among undergraduates in a Nigerian University. Two hundred and ninety three subjects participated in the study. Questionnaires on risk factors and variation of psychoactive substances...

BACKGROUND Asian sand dust (ASD) originates from the arid and semiarid areas of China, and epidemiologic studies have shown that ASD exposure is associated with various allergic and respiratory symptoms. However, few studies have been performed to assess the relationship between skin inflammation and ASD exposure. METHODS Twelve-week-old NC/Nga mice were divided into 6 groups (n = 8 for each ...

Dietary fibers (DF) may affect energy balance, an effect often ascribed to the viscous nature of some water soluble DF, which affect luminal viscosity and thus multiple physiological processes. We have tested the hypothesis that viscous linseed DF reduce apparent nutrient digestibility, and limit weight gain, in a randomized feeding trial where 60 male, growing, Wistar rats, with an initial wei...

[Purpose] This study investigated the effects of walking with talus taping on the ankle dorsiflexion passive range of motion (DF PROM) in individuals with limited ankle DF PROM. [Subjects] Fifteen ankles with limited DF PROM were examined. [Methods] After rigid strapping tape was applied to the ankles from the talus to the calcaneus, progressing posteriorly and inferiorly, the subjects walked o...