Dextromethorphan urinary metabolic ratio is widely used to determine the CYP2D6 phenotype, but its utility to reflect subtle differences in catalytic activity is unclear. We evaluated the capability of dextromethorphan urinary metabolic ratio to predict dextromethorphan oral clearance as a measure of CYP2D6 activity. Data from 10 healthy extensive metabolizers of CYP2D6 were given 30 mg of dext...

Abstract Background Treatments for MDD that can improve both overall depressive and anhedonic symptoms are urgently needed. AXS-05 (dextromethorphan-bupropion) is a novel, oral, investigational NMDA receptor antagonist with multimodal activity being developed MDD. The dextromethorphan component of an sigma-1 agonist. bupropion serves primarily to increase the bioavailability dextromethorphan. O...

Dextromethorphan is an NMDA receptor antagonist in the glutamatergic system. Currently, there are some reports showing that the glutamatergic NMDA receptor mechanism stimulates dopamine release from several brain regions. This effect may in part modulate the stereotyped behaviors of dopaminergic system. The purpose of the present study was to determine the interaction between the blockade of NM...

Background and Aim: Researchers have been in search of medications with less side effects to relieve pain after root canal therapy. This study aimed to assess the efficacy of premedication with oral dextromethorphan and Ibuprofen to decrease pain after endodontic treatment. Materials and Methods: This double blind clinical trial was conducted on 45 patients. The selected teeth had irreversib...

Dextromethorphan at high doses has phencyclidine-like effects on the NMDA receptor system; recreational use of high doses has been found to cause mania and hallucinations. In order to investigate the effects of dextromethorphan on the metabolic capacity of cytochrome P450 (CYP) enzymes, a cocktail method was employed to evaluate the activities of CYP2B1, CYP2D1, CYP1A2, CYP3A2, CYP2C11. The rat...

1. Dextromethorphan is a widely used antitussive agent which is a non-narcotic codeine analogue. We have investigated whether inhaled administration of dextromethorphan provides antitussive activity in a citric acid induced cough model. 2. Twenty normal subjects underwent repeated cough challenge with 5% citric acid. Subjects were studied on six occasions. Study medication consisted of oral dex...

background: cyp2d6 is polymorphically expressed enzyme that show marked interindividual and interethnic variation. phenotyping of cyp2d6 provides valuable information about real-time activity of this important drug-metabolizing enzymes through the use of specific probe drugs. the aim of this study was to identify the cyp2d6 oxidation phenotype with dextromethorphan (dex) as a probe drug in maza...

IMPORTANCE Agitation is common among patients with Alzheimer disease; safe, effective treatments are lacking. OBJECTIVE To assess the efficacy, safety, and tolerability of dextromethorphan hydrobromide-quinidine sulfate for Alzheimer disease-related agitation. DESIGN, SETTING, AND PARTICIPANTS Phase 2 randomized, multicenter, double-blind, placebo-controlled trial using a sequential paralle...

A simple, selective, sensitive and precise, simultaneous high performance liquid chromatographic analysis of syrup containing Chlorphineramine Maleate, Dextromethorphan HBr and Phenylephrin HCl was described. Good chromatographic separation was achieved using a Zorbax C18 (4.6 cm x 250 mm, 5 μm) and a mobile phase consisting of acetonitrile-phosphate buffer pH 3.5 (15:85, v/v) at a flow rate 0....

Dextromethorphan, a noncompetitive blocker of the N-methyl-D-aspartate (NMDA) type of glutamate receptor, at 45, 60 and 75 mg/kg, ip doses induced a behavioural syndrome characterised by reciprocal forepaw treading, lateral head-weaving, hind-limb abduction and flat body posture. Such type of behavioural syndrome is induced by 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT) by directly sti...