In the present study, comprehensive stress testing of Dexketoprofen trometamol was carried out according to ICH guideline Q1A (R2). Dexketoprofen trometamol is subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Additionally, the solid drug is subjected to 50 °C for 60 days in dry-bath, and to the combined effect of temperature and humidity, with and w...

BACKGROUND AND OBJECTIVE In this study, our aim was to evaluate the effects of intravenous dexketoprofen trometamol with ilioinguinal and iliohypogastric nerve block on analgesic quality and morphine consumption after total abdominal hysterectomy operations. METHODS We conducted this randomized controlled clinical study on 61 patients. The study was conducted in the operation room, post-anest...

Objectives: The aim of this prospective randomized, double-blind study was to evaluate the analgesic efficacy and opioidsparing effects of preemptive single dose of dexketoprofen trometamol in comparison with that of paracetamol or placebo for elective lumbar disc surgery, over a 24-hour (h) investigation period. Methods: After institutional approval and informed consent had been obtained, 75 p...

Aims: The aim of this study was to evaluate the pharmacokinetic profiles and relative bioavailability dexketoprofen thiocolchicoside test preparation (dexketoprofen / 25 mg 8 effervescent tablet) in comparison with reference preparations (Keral film coated tablet, containing trometamol equivalent (Menarini International Operations Luxembourg S.A.) (R1) Muscoril capsule, (Sanofi Aventis İlaçları...

Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters we...

BACKGROUND & OBJECTIVES Patients frequently experience pain of moderate to severe degree during gynaecologic procedures. This prospective, randomized, placebo-controlled trial was aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure. METHODS A total...

OBJECTIVE In this study, we aimed comparing early postoperative period analgesic effectiveness and the effects on opioid consumption of intravenous dexketoprofen and lornoxicam that are given preemptively. MATERIALS AND METHODS Forty patients, planned elective mediastinoscopy, were included in this prospective randomized study. These patients were classified in two groups, group D for dexketo...

The aim of the study was to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, and paracervical block with ultracaine on curettage procedure. A total of 111 subjects with the request of pregnancy termination between 5 and 7 weeks of gestation were included in the study. The first group (control group) consisted of 20 parti...

Dexketoprofen trometamol (DT), a nonsteroidal anti-inflammatory drug, is a highly water-soluble salt and active enantiomer of rac-ketoprofen. Its parenteral form is commonly used for acute pain management in emergency departments of our country. Side effects such as diarrhea, indigestion, nausea, stomach pain, and vomiting may be seen after the use of DT. Anaphylactic shock (AS) secondary to in...