INTRODUCTION The purpose of this study was to evaluate the effects of risedronate (Ris) in the modulation of bone formation in rats with glucocorticoid (GC)-induced osteoporosis by histomorphometric, immunohistochemical and gene expression analyses. METHODS We analyzed structure, turnover and microarchitecture, cyclooxygenase 2 (COX-2) levels and osteocyte apoptosis in 40 female rats divided ...

OBJECTIVE To analyze the results of 125 carotid endarterectomies under loco-regional anesthesia, with selective use of shunt and bovine pericardium patch. METHODS One hundred and seventeen patients with stenosis ≥ 70% in the internal carotid artery on duplex-scan + arteriography or magnetic resonance angiography underwent 125 carotid endarterectomies. Intraoperative pharmacological cerebral p...

To evaluate the prevalence of less severe hypercortisolism (LSH) in fractured patients, and its association with hypertension, hyperglicemia, dyslipidemia, obesity. From July 2015 to October 2018 we enrolled all patients admitted our outpatient center for metabolic bone diseases, after exclusion secondary osteoporosis apart from diabetes taking drugs known affect metabolism. In collected data r...

The biochemical and hormonal data in patients with adrenal incidentalomas were evaluated to compare the differences between adrenal adenomas and other benign lesions and to find the relationship between metabolic parameters and adrenal hormones. Ninety two patients (29men, age 20-90 years) with incidentally discovered unilateral or bilateral adrenal masses detected on CT were included in this s...

Anastácio de Queiroz Sousa, F. Roberto Neves Solon, J. Eloy da Costa Filho and F. Heli Cavalcante Lima São José Hospital; Centre of Tropical Medicine of Federal University of Ceará; Fortaleza, CE, Brazil. E-mail: [email protected] This is a 26-year-old man, admitted to the hospital because of severe headache and generalized seizures of 8 day duration, with an average of 6 to 8 episodes a day. He h...

The genetic hallmark of mantle cell lymphoma (MCL) is the translocation t(11;14)(q13;q32), which occurs in more than 95% of the cases. It juxtaposes the cyclin D1 encoding gene CCND1/BCL1/PRAD-1 on 11q13 and the immunoglobulin heavy chain (IGH) gene located on 14q32 [1]. It results in overexpression of the cyclin D1 protein that drives the transition from G1 to S phase of cell cycle. However, t...

One of the first independent clinical trials of Spanish ophthalmology (1) was started in 2005. At that time and to this date, triamcionolone acetonide intra-ocular injections are utilized without a sufficiently demonstrated scientific base, purely on the grounds of isolated clinical cases or small series. For this reason, the Thematic Network 03/13, led by Professor Sánchez Salorio, proposed th...