The planning of a canning line at a drinks manufacturer is discussed and formulated as a mathematical programming model. Several alternative heuristic solution methods are developed, tested and compared on real data, illustrating the trade-offs between solution quality and computing time. The two most successful methods make hybrid use of local search and integer programming, but in rather diff...

But this is only one of the characteristic problems business managers face in dealing with production planning, scheduling, keeping inventories in hand, and expediting. Other questions just as perplexing and baffling when managers approach them on the basis of intuition and pencil work alone-are: How often should we reorder, or how should we adjust production, when sales are uncertain? What cap...

In the manufacture of certain products such as computers, turbines, and automobiles, various components and subassemblies must be combined in a specified assembly order over a period of time. Certain items must be on hand before others can be produced, and these requirements are determined by the product structure. Management's objective is to turn out timely products in the most economic ...

There are many challenges to be faced when conducting randomized controlled trials (RCTs) in pediatric research. One important challenge is the determination of an appropriate sample size. Recruiting more children than necessary risks unnecessary overexposure of children to an inferior treatment, whereas underestimating the sample required will lead to inconclusive or unreliable results. Both o...

the problem of determining the sequence of a set of jobs with the objective function of minimizing the maximum earliness and tardiness in one machine is studied. production systems like jit are one of the many applications of the problem. this problem is studied in special cases and their optimal solutions are introduced with simple orders. in general, some effective conditions for neighboring ...

The problem of determining the sequence of a set of jobs with the objective function of minimizing the maximum earliness and tardiness in one machine is studied. &#10 Production systems like JIT are one of the many applications of the problem. This problem is studied in special cases and their optimal solutions are introduced with simple orders. In general, some effective conditions for ne...

The problem of determining the sequence of a set of jobs with the objective function of minimizing the maximum earliness and tardiness in one machine is studied. Production systems like JIT are one of the many applications of the problem. This problem is studied in special cases and their optimal solutions are introduced with simple orders. In general, some effective conditions for neig...